 | | Vol. 8.10 – 18 March, 2022 |
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| Investigators showed that terminal sialylation of glycans on intestinal mucus by alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 was essential for mucus integrity and protected against excessive bacterial proteolytic degradation.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors demonstrated that Lepr+ mesenchymal cells surrounding intestinal crypts sensed diet change and provided a novel niche signal to maintain intestinal stem cell and progenitor cell proliferation.
[Cell Research] |
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| To gain insights into the pharmacobiology of human colorectal cancer, scientists created a robust drug screening platform for patient-derived colorectal organoids.
[Nature Chemical Biology] |
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| Researchers identified miR-148a as a targetable element upstream of pregnane X receptor (PXR) signaling in cancer stem cells, which when over-expressed decreased PXR expression and impaired tumor relapse after chemotherapy in mouse tumor xenografts.
[Stem Cell Reports] |
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| In vitro genetic ablation of golgi phosphoprotein 3 (GOLPH3) was performed using small interfering RNA transfection, and a stably overexpressed GOLPH3 colon cancer cell line was constructed using the lentivirus system.
[Frontiers in Molecular Biosciences] |
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| Investigators performed a label-free proteomic analysis of exosomes from a pair of homologous human colorectal cancer cell lines with different metastatic abilities.
[Translational Oncology] |
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| Scientists addressed the inter-relationship between the coiled-coil domain-containing protein 43 (CCDC43) and four and a half LIM domains 1 (FHL1) in modulating gastric cancer cells growth and apoptosis.
[Experimental Cell Research] |
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| OSI-027 dose-dependently reduced colon cancer cell viability through inducing the cell apoptosis and induced the apoptosis of colon cancer cells via upregulation of p53-upregulated modulator of apoptosis (PUMA).
[Cell Biology International] |
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| Researchers investigated the effect and efficacy of 2-pyridin-4-yl methylene β-boswellic acid (PMBA) and 5-FU in combination therapy compared in the treatment of KRAS mutant colon cancer.
[Heliyon] |
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| Investigators discuss how recent findings on diffuse-type gastric cancer (DGC) are leading towards an understanding of the cellular and molecular mechanisms responsible for DGC initiation and malignancy.
[Biochimica et Biophysica Acta-Reviews On Cancer] |
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| The authors describe the effects of various immune cells on intestinal stem cells (ISCs), as well as the mechanisms underlying these effects and also highlight the remarkable role of ISCs in intestinal pathogenesis.
[Stem Cell Reviews and Reports] |
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| A Saint Louis University (SLU) School of Medicine physician-scientist has received funding from the National Institutes of Allergy and Infectious Diseases of the National Institutes of Health (NIH) to study short bowel syndrome.
[Saint Louis University] |
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| Hundreds of newly diagnosed bowel cancer patients in Yorkshire will have the opportunity to take part in two international clinical trials.
[University of Leeds] |
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| April 7 – April 9
Rome, Italy & Virtual |
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| | Cancer Research UK Beatson Institute – Glasgow, Scotland, United Kingdom |
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| | University of Southern Denmark – Odense M, Denmark |
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| | Columbia University – New York, NY, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | University of Virginia School of Medicine – Charlottesville, Virginia, United States |
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