[Nature Aging] Researchers presented the Human Aging Endothelial Cell Atlas, a harmonized single-cell transcriptomic compendium of over 375,000 endothelial cells from 12 human tissues throughout adulthood.

[Cardiovascular Research] Scientists identified a previously unreported long noncoding RNA, Aging Associated Transcript (lncAAT), which is significantly upregulated in senescent endothelial cells in human vessels.

[Cardiovascular Research] As endothelial dysfunction critically drives post-myocardial infarction remodeling, investigators hypothesized that β3 adrenergic receptor (ADRB3) preserves endothelial integrity and protects the heart from ischemic injury.

[Proceedings of the National Academy of Sciences of the United States of America] The authors showed that endothelial programmed cell death ligand-1 (PD-L1) is regulated by leptin receptor signaling in male mice and in particular, endothelial PD-L1 expression is affected by leptin resistance.

[ACS Applied Materials & Interfaces] Researchers developed a polyacrylamide hydrogel platform with tunable stiffnesses covering the pathophysiological range of Descemet’s membrane to investigate stiffness-dependent lipid metabolic reprogramming in human corneal endothelial cells.

[Pharmacological Research] By integrating single-cell and spatial transcriptomics, scientists identified a pathologically expanded atypical chemokine receptor 1 (ACKR1+) endothelial cell subpopulation that correlates with pulmonary function decline and forms a pro-fibrotic endothelial-fibroblast niche in idiopathic pulmonary fibrosis.

[Cell Reports] Researchers investigated the effects of VEGF-C on the therapeutic efficacy of avian paramyxoviruses (APMVs) in mouse melanoma and showed that VEGF-C markedly enhances anti-tumor immune responses induced by APMVs.

[Blood Advances] Investigators assessed the impact of recombinant FVIII products with molecular modifications to extend half-life and those without modifications, as well as emicizumab (a bispecific antibody), on blood outgrowth endothelial cells derived from hemophilia A patients, whose cellular functions were previously shown to be defective.

[Acta Pharmacologica Sinica] The authors investigated whether dimethyl fumarate (DMF) exerts its vascular benefits via the transcription factor EB (TFEB) pathway. Specifically, they examined the effect of DMF on TFEB phosphorylation and activity and assessed whether such changes underlie improvements in endothelium-dependent vasorelaxation.

[Journal of Ethnopharmacology] Scientists aimed to investigate the inhibitory effects of sinensetin on choroidal neovascularization and to dissect the underlying mechanism, specifically focusing on its modulation of fibroblast growth factor 1-mediated mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling.

[PloS One] Researchers aimed to investigate the impact of transient receptor potential melastatin 7 (TRPM7) on cell proliferation, vascular formation and migration in diabetic foot by isolating primary human foot vascular endothelial cells and modulating the expression of TRPM7 through knockdown and overexpression approaches.

[Medicinal Research Reviews] The authors look closely at cell intercommunication in the fat depot and discuss the main events occurring in adipose tissue associated with the progressive tissue dysfunction that happens in obesity: adipocyte metabolism, angiogenesis, and extracellular matrix remodeling.