[Muscular Dystrophy Canada] Muscular Dystrophy Canada announced the launch of the Neuromuscular Disease Real-World eXperience Registry designed to reshape neuromuscular research, policy, and care.

[Tenaya Therapeutics, Inc.] Tenaya Therapeutics, Inc. announced that the US FDA has granted Regenerative Medicine Advanced Therapy (RMAT) designation to TN-401, Tenaya’s gene therapy candidate for the treatment of PKP2-associated arrhythmogenic right ventricular cardiomyopathy.

[Science Translational Medicine] Scientists performed single-nucleus RNA sequencing of cardiac tissues from 47 patients with hypertrophic cardiomyopathy and compared them with nonfailing donor and dilated cardiomyopathy hearts to investigate stage- and genotype-specific disease mechanisms.

[Cardiovascular Research] Researchers revealed that a CD36/FABP5/PPARδ signaling axis is essential for spontaneous neonatal cardiomyocyte proliferation, and re-activating this pathway in adult hearts is sufficient to induce functional recovery after ischemic injury.

[JCI Insight] Investigators developed a computational network model of DYRK1A-mediated regulation of the cell cycle, which predicts how DYRK1A inhibition promotes cardiomyocyte re-entry. Results were validated in neonatal rat cardiomyocytes.

[British Journal of Pharmacology] Scientists investigated the role of cardiomyocyte exostosin-1 (EXT1) in myocardial ischaemic injury using genetic and pharmacological approaches in vitro and in vivo.

[Diabetes] The authors investigated the role of Cryab in diabetic cardiomyopathy (DbCM) and its lysine lactylation (Kla), demonstrating that reduced Kla modification in Cryab contributes to cardiac dysfunction associated with DbCM.

[Elife] Researchers used the culture of fluorescent sarcomere-reporter human induced pluripotent stem cell-derived cardiomyocytes (CMs) and found that increasingly stiff substrates inhibited overall CM contraction, but did not diminish individual sarcomere dynamics.

[Acta Pharmacologica Sinica] Scientists investigated the effects of tectorigenin, a bioactive isoflavone derived from traditional Chinese medicine, on heart failure with preserved ejection fraction (HFpEF) and elucidated the underlying molecular mechanisms.

[Pharmacological Research] Investigators revealed that glucocorticoid induces cellular senescence of fibro-adipogenic progenitors, leading to their accumulation in skeletal muscle.

[Communications Biology] The authors provided a comprehensive molecular atlas of the neuromuscular junction in the diaphragm and open new opportunities to dissect the synaptic mechanisms underlying respiratory function and neuromuscular diseases.

[Biological Trace Element Research] Researchers investigated the effects of copper sulfate on myogenic differentiation of bovine skeletal muscle-derived cells and the underlying molecular mechanisms.