[Nature Cell Biology] Through multi-omics, pan-cancer analysis, and multiple tumour-bearing models, investigators identified THY1^⁺ CSCs as the key drivers of metastasis and uncover a previously unrecognized ‘pseudohypoxic’ state as a central regulatory factor.

[Advanced Science] The authors integrated single-cell RNA sequencing with spatial transcriptomics to systematically define CSC-associated phenotype in NSCLC. Weighted gene co-expression network analysis identified a 127-gene CSC signature enriched for stemness-related pathways.

[Advanced Science] Researchers identified circRNAs with key roles in promoting hepatocellular carcinoma (HCC) malignancy and stemness properties. Through circRNA profiling comparison in HCC patients and functional screening in HCC cells, circRSU1 emerges as the top candidate.

[Cell Death & Disease] Mechanistic investigations revealed that KIF20A regulates DHX9 nucleocytoplasmic distribution and inhibits TRIM21-mediated K48-linked polyubiquitination at DHX9-K755, thereby preventing its proteasomal degradation and enhancing protein stability.

[Oncogene] Investigators revealed for the first time that 25-Hydroxyvitamin D (25(OH)D) exerts antitumor effects by promoting exon 13 skipping of KDM6A, which suppresses the proliferation and stemness of breast cancer cells and lacks H3K27 demethylase activity.

[FASEB Journal] Scientists elucidated the functional role of the potassium channel tetramerization domain 15 (KCTD15) in triple-negative breast cancer progression, providing mechanistic insights into its potential as a therapeutic target for this challenging disease.

[Discover Oncology] The authors synthesize current preclinical and clinical advancements in targeting CSCs via DNA damage response inhibitors, including PARP, ATR, ATM, and DNA-PKcs inhibitors, as well as emerging synthetic lethality targets.

[Novocure] Novocure announced that the US FDA approved Optune Pax^® for the treatment of adult patients with locally advanced pancreatic cancer concomitant with gemcitabine and nab-paclitaxel.

[SURGE Therapeutics (Business Wire, Inc.)] SURGE Therapeutics announced the final patient has been dosed in its Phase I clinical trial of SRG-514, an investigational therapy for breast cancer patients undergoing surgery.

[Signal Transduction and Targeted Therapy] Using genetic ablation studies, investigators showed that Protein kinase C-eta (PKCη)- promotes metastasis by enhancing epithelial‒mesenchymal transition and stemness. Notably, compared with those in PKCη-intact tumors, orthotopic xenografts of PKCη-knockout cells in NSG mice resulted in reduced tumor growth and metastasis.

[Nature Aging] Researchers showed that during mammary gland involution in mice, a p16^Ink4a-dependent senescence response is induced in alveolar luminal cells. Eliminating senescent cells disrupts tissue remodeling and delays involution, demonstrating their physiological importance.

[Cell Death & Disease] Scientists investigated the functional interplay between lysine demethylase 5B (KDM5B) and the Cullin-RING ligase 4B (CRL4B) complex in modulating cholesterol metabolism to promote estrogen receptor-positive (ER+) breast cancer progression.