[OncoRes Medical] OncoRes Medical announced its evolution to Ziva Surgical, unveiling a new name and visual identity as the Australian tissue intelligence company enters a defining chapter in its mission to transform how solid tumor cancers are detected during surgery.

[MECCC] The National Cancer Institute has awarded a multidisciplinary and multi-institutional team led by Dr. Julio Aguirre-Ghiso of Montefiore Einstein Comprehensive Cancer Center (MECCC), a five-year, $10 million grant to uncover the biological processes that drive breast cancer relapse.

[Cancer Cell] Researchers established large-scale breast cancer cohorts integrating AI-powered computational pathology and single-cell spatial omics to investigate the clinical relevance and biological mechanisms underlying neutrophil spatial patterns.

[Drug Discovery Today] The authors highlight the diverse functions of exosomes in the treatment of breast cancer, with a special focus on the use of engineered exosomes as nanocarriers for the delivery of doxorubicin, paclitaxel, and nucleic acids such as small interfering RNAs and microRNAs.

[Nature] Investigators extensively profiled epigenetic heterogeneity in a cohort of treatment-naive human luminal tumors. They identified a recurrent subpopulation of basal-like cells in luminal tumours with a conserved epigenetic signature across patients.

[Nature Genetics] Scientists performed saturation genome editing (SGE) in human HAP1 cells to test 4,740 BRCA1 variants and develop an additional SGE assay in human mammary epithelial cells to systematically compare variant effects.

[Signal Transduction and Targeted Therapy] Researchers identified and molecularly characterized a previously unrecognized form of E-cadherin internalization in mammary epithelial cells.

[Experimental Hematology & Oncology] The authors synthesize evidence on tumor-intrinsic determinants of the immune-cold phenotype in breast cancer under an operational framework, comprising three functionally defined domains.

[Scientific Reports] Scientists investigated the potential of Ajwain essential oil in reversing epithelial-to-mesenchymal transition (EMT) linked to modulation of the PTEN–AKT2 axis, along with its anti-proliferative properties, in MDA-MB-231 cells.

[Cell Chemical Biology] Researchers showed that two benzothiophene analogs, SIMMPYRA1 and SIMMPYRA2, trigger cell death in TNBC cells and block tumor growth in patient-derived xenograft models in vivo by selectively blocking STAT3 activity.

[Cancer Cell] Researchers demonstrated that attenuated interferon response signaling characterizes a subset of patient-derived organoids intrinsically resistant to KRAS^G12D-targeted therapy.

[Science Advances] Scientists used a highly complex skin organoid model generated from hiPSCs for the analysis of herpes simplex virus 1 pathogenesis in the skin.