[Signal Transduction and Targeted Therapy] Researchers identified p16 as a mechanistically defined regulator of fibrosis progression and suggested that modulating this axis may offer new opportunities for therapeutic intervention in idiopathic pulmonary fibrosis.

[Bioorganic Chemistry] Investigators identified RING-box protein 1 (RBX1) as a critical regulator of airway epithelial injury, whose expression is markedly elevated in asthma.

[Cell] Scientists addressed the origins of the signature, first determining that basal, club, neuroendocrine, and AT2 epithelial lineages were competent to form EGFR-driven lung adenocarcinoma, with conserved keratin 8⁺ alveolar intermediate cell-like states observed within the alveolar niche.

[Proceedings of the National Academy of Sciences of the United States of America] Through an integrated screening combining bioinformatics, transcriptomics, and clinical prognostic analysis, the authors identified E3 ubiquitin ligase SPOP as a key tumor suppressor in lung adenocarcinoma.

[Biochemical Pharmacology] Using multiple experimental approaches, including the Cell Counting Kit-8 assay, colony formation assay, flow cytometry, RNA sequencing, and Western blot analysis, investigators systematically evaluated the in vitro effects of Carnosol on lung cells

[Clinical and Experimental Medicine] Researchers identified the pyrroline-5-carboxylate reductase 1 (PYCR1)/OPLAH axis as a key driver of LUAD progression via p53 signaling, revealing a promising therapeutic target.

[Discover Oncology] Scientists highlight the effectiveness of in-silico methods in identifying promising phytochemicals, such as quercetin and curcumin, that target key molecular pathways in lung cancer.

[University of Houston] Two new grants from the Cancer Prevention and Research Institute of Texas (CPRIT) bring the total of active CPRIT grants at UH to $11.1 million, and both are meant to develop new strategies to fight lung cancer.

[Signal Transduction and Targeted Therapy] Investigators identified histaminylation in cardiac type I collagen isolated from mice 7 days after acute myocardial infarction by mass spectrometry.

[Journal of Clinical Investigation] Researchers studied the role of macropinocytosis in experimental pulmonary fibrosis models. They found that macropinocytosis is increased in human lung fibroblasts derived from patients with idiopathic pulmonary fibrosis.

[Nature Communications] Scientists mapped the fibroblast transcriptional response to stretching in vivo and demonstrate that stretching forces fibroblasts to exit their quiescent state and restart proliferation.

[Nature Communications] Investigators reported that ECM immunomodulation in triple-negative breast cancer is mediated by post-translational glycan modifications on ECM proteins.