[ACS Nano] Researchers uncovered a reactive oxygen species-mediated crosstalk between ferroptotic liver cancer cells and hepatic stellate cells that may promote liver fibrosis.

[Nature Communications] Scientists identified AREL1 as a key driver of hepatic stellate cell activation in MASH-related fibrosis and showed that targeted AREL1 silencing with vitamin A–guided nanoparticles significantly reduces liver fibrosis.

[Cancer Research] Using patient-derived organoids (PDOs) and orthotopic HCC xenograft models, investigators uncovered a role for EGFR in lenvatinib resistance.

[Cancer Letters] The authors found that HCC cells cultured with postoperative serum exhibited enhanced anoikis resistance, invasion, migration, and increased potential for lung metastasis compared to those cultured with preoperative serum.

[Cell Death & Disease] Scientists investigated their roles in hepatocarcinogenesis and malignant progression. Western blotting and membrane biotinylation assays revealed that EphA2-C-terminal fragment was present in HCC cells co-expressing EphA2 and MT1-MMP.

[Scientific Reports] Researchers combined tissue engineering with hypoimmunogenic iPSC technology to generate off-the-shelf hepatic organoids that integrate parenchymal and non-parenchymal cells.

[Human Cell] Investigators identified CCR4-NOT transcription complex subunit 9 (CNOT9) as a driver of liver cancer progression, promoting proliferation and cell cycle progression through the PTEN/AKT/p53 signaling pathway.

[Reviews in Endocrine & Metabolic Disorders] Scientists investigate aldosterone's role in metabolic dysfunction, linking it to adipose tissue dysfunction, systemic insulin resistance, and the development and progression of metabolic dysfunction–associated steatotic liver disease.

[Virginia Commonwealth University] A new imaging center at the Stravitz‑Sanyal Institute for Liver Disease and Metabolic Health at Virginia Commonwealth University will help researchers develop better treatments for liver disease

[Journal of the American Chemical Society] Researchers developed an inhalable enzyme-activated polymeric proteolysis-targeting chimera (PROTAC) nanococktail that enables concurrent degradation of two key profibrotic signaling regulators in fibrotic lungs.

[EMBO Reports] By using mouse stem cell lines, scRNA-seq, and transcriptomic and chromatin accessibility profiling, scientists showed that Foxe1 knockout impairs Nkx2-1+ cell differentiation and maturation into thyroid follicular-like cells.

[Cancer Discovery] Investigators discovered that breast cancer–derived lung metastases stimulate the proliferation of alveolar type II (AT2) cells in their vicinity and reprogram them into lipid feeder cells in mice and patients using spatial analysis.