[United Therapeutics Corporation] United Therapeutics Corporation announced that the US FDA has granted clearance under the company’s investigational new drug application to proceed with the SUMMIT clinical trial of treprostinil soft mist inhaler in pulmonary hypertension associated with chronic obstructive pulmonary disease (PH-COPD).

[Omeros Corporation] Omeros Corporation announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency issued a negative opinion on the company’s marketing authorization application for narsoplimab for the treatment of hematopoietic stem cell transplant-associated thrombotic microangiopathy (TA-TMA).

[Elevar Therapeutics, Inc.] Elevar Therapeutics, Inc. announced the resubmission of a New Drug Application to the US FDA for its investigational drug rivoceranib, an oral VEGF-TKI, in combination with camrelizumab, an anti-PD-1 antibody, as a first-line systemic treatment option for unresectable or metastatic hepatocellular carcinoma.

[Blood] Researchers assessed iron levels across the vascular endothelium in mouse and human endothelial cells and found that resistance artery endothelial cells have the lowest iron stores, suggesting they may be especially affected by iron deficiency.

[Cell Stem Cell] Scientists generated vascularized pancreatic islet organoids (PIOs) by co-culturing PIOs with blood vessel organoids (BVOs), resulting in integrated structures with BVOs-derived capillary networks that penetrate into the islet structures.

[Advanced Science] The authors established a novel cisplatin (CDDP)‑induced rat model and identified a conserved Fanconi anemia complementation group L (FANCL)–DNA damage–endothelial dysfunction mechanistic axis underlying pulmonary arterial hypertension (PAH) with pulmonary veno-occlusive disease (PVOD) induced by mitomycin C or CDDP.

[Acta Neuropathologica] Investigators performed a quantitative single-vessel analysis of the human cortical microvasculature across increasing cerebral small vessel disease severity and aging.

[Science Advances] Researchers selectively targeted the mitochondrial carbonic anhydrase (CA) isoform CA-VB by pharmacological and genetic manipulation in human cerebral microvascular endothelial cells, and confirmed the protective effects of the CA-V inhibitor in Alzheimer’s disease mice.

[Angiogenesis] The authors presented a novel in vitro differentiation protocol for generating murine lymphatic endothelial precursor cells from stromal vascular fraction, dermis, and bone marrow-derived mesenchymal stem cells.

[Pharmacological Research] Scientists revealed that alpha-ketoglutarate exerts broad anti-fibrotic effects in systemic sclerosis models by protecting endothelial function and inhibiting canonical pro-fibrotic signaling.

[JCI Insight] Researchers identified a previously unrecognized population of lung capillary endothelial progenitor cells coexpressing c-KIT and FOXF1 in adult human and mouse lungs.

[British Journal of Pharmacology] Investigators identified ginsenoside Ra1 as a potential inhibitor of non-muscle myosin heavy chain IIA and provided mechanistic insight into therapeutic strategies targeting endothelial dysfunction in sepsis.