[FibroBiologics, Inc.] FibroBiologics, Inc. announced that the European Patent Office has granted European Patent No. EP 4454709, titled "Fibroblast Delivery of Tumor Inhibitory Agents. The patent covers methods of preparing fibroblasts as anti-cancer delivery compositions by modifying the cells to improve their ability to home to cancer cells.

[Applied Biologics, LLC.] Applied Biologics, LLC. announced the completion of enrollment into the sentinel safety cohort of its Phase III randomized controlled clinical trial evaluating BIOxHEAL^™ in patients with chronic, nonhealing diabetic foot ulcers.

[StimLabs ] StimLabs announced the commercial launch of DermaForm, an FDA 510(k)-cleared porcine-derived particulate collagen scaffold that manages a range of acute and chronic wounds.

[npj Biological Physics and Mechanics] Using Schlemm’s canal (SC) cell primary cultures from normal and glaucomatous human eyes as well as mouse whole eye perfusion, researchers identified microtubules as a key component of the mechanotransduction machinery linking the mechanical microenvironment to SC cell biomechanics and conventional outflow.

[Biofabrication] Scientists developed a xeno-free, spatially organized 3D synovial membrane model that reconstructs the structural relationship between the macrophage lining and fibroblast-rich sublining compartment.

[Annals of the Rheumatic Diseases] Researchers investigated the role of nicotinamide N-methyltransferase (NNMT) in dermal fibroblast activation and fibrosis in systemic sclerosis. NNMT supported TGFβ-induced activation of an ATF4/SOX9/SRF transcriptional network that contributed to ECM gene expression and collagen secretion.

[Experimental & Molecular Medicine] Combining patient-derived ex vivo carboplatin screening with bulk and single-cell transcriptomics, functional perturbation in cancer-associated fibroblasts, and high-resolution spatial transcriptomics, scientists identified stromal apolipoprotein L4 (APOL4) as a biomarker of platinum sensitivity.

[Advanced Science] Investigators applied size-based fractionation to separate infusible decellularized ECM into its main components, enabling us to study how each component behaves in the context of inflammation and acute myocardial infarction.

[Advanced Materials] Scientists designed dynamic granular hydrogels that are modularly assembled using microgels with pre-programmed and precise degradation rates ranging from a few days to several weeks. The biological significance of timed pore expansion in dynamic granular hydrogels was investigated in a mouse muscle crush injury model.

[Acta Biomaterialia] Investigators developed an RQK-based strategy for functional dental pulp regeneration by integrating ECM-like architecture with instructive bioactive cues in a self-assembling hydrogel system.

[Signal Transduction and Targeted Therapy] The authors dissect the multifaceted roles of cancer-associated fibroblasts, from their promotion of cancer cell proliferation, invasion, and angiogenesis through secreted factors and extensive ECM remodeling, to their profound influence on the immune landscape.

[Developmental Cell] Researchers identified the pulmonary disease-associated ATP-binding cassette transporter A3, a regulator of surfactant lipid accumulation, as a vesicle-associated membrane protein-associated protein A (VAPA) interactor.