[Nature Communications] Investigators showed that its major driver oncogene KRAS activates the cGAS-STING-TBK1 axis, inducing a type I interferon response that primes PDAC cells for necroptosis.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists designed a mouse model that enables pulldown of endogenous BiP selectively from β cells and reveals chaperone complexes that coordinate to limit proinsulin misfolding.

[npj Precision Oncology] Researchers identified Wolfram syndrome 1 (WFS1) as a potential molecular vulnerability in KRAS^G12D-driven PDAC. Their findings suggest that WFS1 expression is upregulated following KRAS^G12D activation and may promote tumorigenesis and metastasis.

[JCI Insight] Scientists identified a subpopulation of senescent β cells expressing p21, which emerged early in the progression of T2D in humans and mice.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators demonstrated that genetic ablation of three independent nodes involved in downstream, upstream, and orthogonal KRAS signaling pathways leads to complete and permanent regression of orthotopic PDACs induced by Kras/Tp53 mutations.

[Cell Death Discovery] Using robust 3D co-culture systems, samples from PDAC patients and murine in vivo models, researchers described a novel immune evasion mechanism used by PDAC to inhibit the anti-tumor activity of B lymphocytes.

[Oncogenesis] Through integrated analysis of clinical specimens and transcriptomic datasets, researchers identified significant enrichment of neuroendocrine differentiation markers correlating with poor patient outcomes.

[Annals of Medicine] Scientists highlight how non-coding RNAs drive aerobic glycolysis and metabolic reprogramming in pancreatic cancer, revealing new opportunities for biomarkers and targeted therapies.

[Journal of Molecular Endocrinology] The authors focus on pancreatic β cell aging in physiological and diabetic conditions and examine the emerging role of m⁶A methylation in aging and diabetes progression.

[University of Barcelona] Dr. Elisa Espinet has received a FERO Foundation Young Researchers Grant to study the mechanisms behind response and resistance to emerging pancreatic cancer therapies.

[Nature Communications] Scientists investigated how Myosin Light Chain Phosphorylatable Fast (Mylpf) abundance impacts sarcomere growth. The two zebrafish Mylpf genes, mylpfa and mylpfb, are exclusively expressed in fast-twitch muscle, with mylpfa expressed more abundantly than mylpfb.

[Nature Biomedical Engineering] Researchers reported the systemic delivery of skeletal-muscle-targeted full-length DMD mRNA in a murine model of Duchenne muscular dystrophy (DMD) using allogenically engineered targeting extracellular vesicles.