[Nature] Scientists established mosaic analysis with double markers technology in mouse embryonic stem cells to probe radial glial progenitor lineage progression in a self-organizing cortical organoid system.

[Developmental Cell] The authors generated elongating heart organoids from hiPSCs that undergo coordinated elongation and looping-like curvature, resembling early cardiac morphogenesis.

[Journal of Advanced Research] Researchers established a high-fidelity mouse skin organoid platform to simulate clinically relevant stressors and identify the core regulatory components of the regenerative program.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators developed an Epstein–Barr virus human tonsil organoid model to evaluate key B cell states and antiviral responses, including after primary infection.

[Stem Cell Reports] To better model human disease, researchers generated Methyltransferase-like 5 (METTL5)-KO hiPSC-derived cortical organoids, which exhibit impaired neural progenitor cell proliferation and differentiation.

[Stem Cell Reports] Scientists established a macrophage-organoid co-culture integrating bone marrow-derived macrophages (BMDMs) into the intestinal niche to create a controlled, immune-competent system.

[Cell Proliferation] The authors systematically summarize current fabrication strategies, disease-modeling utilities and regenerative potentials of liver organoids, alongside the major challenges and future directions.

[Bone Research] Investigators review focus on elucidating the potential relationship between interoception and organoids.They highlight three types of organoids that demonstrate interoceptive connections with the central nervous system and emphasize their potential relevance to the gut-brain axis, bone-brain axis, and neurological disorders.

[GOV·UK] New projects to move UK science away from animal testing – vital to the safety and sustainability of our environment – will unlock new tests for products that can help products reach market more quickly and save lives.

[Nature] Investigators showed that restoring plasticity in parvalbumin neurons can improve cognition and suppress seizures in a neurodevelopmental disorder model, suggesting that some developmental circuit deficits may be reversible in adulthood.

[Nature Genetics] Scientists developed a high-content screening to investigate how Alzheimer’s disease genetic risk factors may affect synaptic mechanisms in rat primary neuronal cultures.

[Nature Neuroscience] Researchers developed STARFISH, a method for visualizing the subcellular site of endogenous mRNA translation in primary neurons and in vivo with single-molecule sensitivity and near-codon resolution, without modifying the nascent polypeptide.