[The International Society for Stem Cell Research] The International Society for Stem Cell Research (ISSCR) announced the launch of its new ISSCR contract development and manufacturing organization (CDMO) Directory, a web-based screening resource designed to help researchers identify CDMOs with capabilities relevant to advancing stem cell research toward clinical applications.

[Medera Inc.] Medera Inc. announced that Novoheart is contributing its proprietary human cardiac technologies to the newly launched Centre for Integrative Human Cell Research and Translation (CIPHER), the first centre in the Asia-Pacific region dedicated to cardiovascular stem cell research and translational drug discovery using human heart cells derived from blood samples of Asian patients.

[Magellan Stem Cells] Charles River Laboratories International has announced a new partnership with Magellan Stem Cells to support Magellan in the development and clinical advancement of its proprietary stem cell-based therapies and regenerative medicine solutions.

[Upstate Medical University] Upstate Medical University has been awarded $1.5 million by New York state to create an advanced research center for brain diseases. Upstate will establish the Biospecimen-iPSC-Organoid Node, which will integrate biospecimens, induced pluripotent stem cells and organoid models to support human-centered neuroscience research.

[Nature] Scientists established conditions that enable the continuous ex utero development of mouse embryo models, starting solely from chemically induced totipotent-like stem cells and spanning the pre-implantation morula, blastocysts, and post-gastrulation stages with both embryonic and extraembryonic compartments.

[Nucleic Acids Research] The authors profiled circular RNA (circRNA) and messenger RNA expression during differentiation of hESCs into five germ layer–derived lineages, identifying a circRNA-mediated mechanism that uncouples cyclin-dependent kinase (CDK)-activating kinase complex activity to modulate stem cell fate.

[Neuron] Researchers profiled 85 human iPSC lines carrying MAPT mutations and isogenic controls using whole-genome sequencing, long-read sequencing of the MAPT locus, bulk and single-cell RNA sequencing, and DNA methylation arrays.

[Nature Chemical Biology] Investigators identified PUS7 as an RNA modification checkpoint that promotes acquisition of pluripotency and and established PUS7, SOX2, KLF4, and MYC as a framework for generating high-quality human iPSCs for modeling and regenerative medicine.

[Stem Cell Reports] Scientists analyzed hundreds of RNA sequencing (RNA-seq) samples of CRISPR-edited iPSC lines for 66 genes and the matched single-neuron RNA-seq data.

[Archives of Toxicology] Researchers investigated the mechanisms underlying associations between maternal lead exposure and adverse pregnancy and birth outcomes at the transcriptional level using hESCs.

[Stem Cells and Development] The authors functionally characterized a genetically defined acute myeloid leukemia (AML)-iPSC resource comprising 34 AML-iPSC lines from 11 AML patients, with complementary assays performed across partially overlapping subsets of lines.

[Biology of Reproduction] Researchers identified defined biochemical conditions that enable efficient conversion of porcine expanded PSCs into induced trophoblast stem cells.