[Rubedo Life Sciences (BusinessWire)] Rubedo Life Sciences announced a new clinical study of investigational RLS-1496 in patients with androgenetic alopecia, the most prevalent form of hair loss globally, beginning October 2026

[LEO Pharma] LEO Pharma announced that the US FDA has accepted for filing and granted Priority Review to the New Drug Application for dersimelagon, a potential first-in-class oral therapy for erythropoietic protoporphyria and X-linked protoporphyria, two rare genetic skin diseases.

[LEO Pharma] LEO Pharma announced that the Committee for Medicinal Products for Human Use (CHMP) has adopted a positive opinion recommending a label expansion for Anzupgo® (delgocitinib) cream to include adolescents aged 12 to 17 years with moderate to severe chronic hand eczema.

[Advanced Science] Scientists introduced a matrix metalloproteinase (MMP)-9-responsive protein release system (M9RR) as a therapeutic strategy for Diabetic Foot Ulcer. M9RR demonstrates MMP-9 specificity, broad mammalian cell applicability, and protection of HaCaT keratinocytes and BJ fibroblasts from MMP-9-induced damage.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers identified the calcium-permeable cation channel transient receptor potential vanilloid 4 (TRPV4) as an important mediator of low-humidity responses in epidermal keratinocytes.

[Elife] Investigators used in vivo live imaging to analyze wound-induced syncytia in mitotically competent Drosophila pupae, finding almost half the epithelial cells near a wound fuse to form large syncytia.

[International Journal of Biological Macromolecules] Scientists developed a molecularly defined recombinant human COL3A1-derived collagen-like protein, termed recombinant humanized type III collagen, for the topical repair of acute UV-induced skin injury.

[European Journal of Pharmacology] The authors investigated the concentration dependent effects of sitagliptin on HaCaT keratinocytes and primary fibroblasts in vitro and explored the molecular pathways involved.

[Science Translational Medicine] Scientists used cutaneous ultraviolet (UV) B photoexposure of healthy controls and patients with systemic lupus erythematosus to provide an atlas of the cutaneous inflammatory response 24 hours after UV exposure in single-cell resolution.

[EBioMedicine] Researchers investigated the functional role and mechanisms of natural killer cells in elderly atopic dermatitis pathogenesis using single-cell RNA sequencing complemented by flow cytometry and immunofluorescence.

[Cell Reports] The authors showed that TP73, together with TP63, is upregulated in skin squamous cell carcinoma and is required for tumorigenesis. They found that p63 and p73 form heteromeric complexes and co-occupy distal enhancers, creating a shared regulatory framework.

[Mucosal Immunology] Scientists examined the consequences of kallikrein 5 deficiency following exposures to the type 2-provoking agent calcipotriol in mice, finding exacerbated atopic dermatitis-like responses including increased accumulation of skin eosinophils and langerhans cells, over-expression of an array of cytokines in the skin, and scratching behaviour.