[Stem Cell Reviews and Reports] Scientists review the organoid work across the gut, liver, and lung and propose that the two orthogonal axes of advancement be analyzed separately.

[Nature] The authors established a transplantation platform using a genetic strategy to effectively deplete glutamatergic neurons from mouse neocortex and hippocampus (apallial) and neonatally engraft the cortical cavity with human stem-cell-derived cortical organoids to generate xenocortical mice.

[Molecular Therapy Oncology] When human peripheral blood mononuclear cells from healthy and cancer patients (who exhibit systemic dysregulation) were exposed to NK cell-derived extracellular vesicles, widespread shifts in gene activity occurred across key immune populations, notably CD8+ T cells and NK cells.

[Nature Protocols] The authors present protocols for long-term imaging and quantitative analysis of intestinal organoids. They outline strategies for optimizing organoid health, imaging conditions, and experimental interventions to ensure efficient downstream analysis,

[AZO Life Sciences] With support from a $72,419 grant, University of Arkansas at Little Rock researcher Dr. Sujan Ghosh is developing a 3D tissue scaffold that more closely mimics the microscopic architecture of the human small intestine.

[AptarGroup, Inc.] AptarGroup, Inc. announced that it has signed an agreement for a research collaboration led by Dr. Alice Stanton from Massachusetts General Hospital to advance the science of nose-to-brain drug delivery.

[Stem Cell Reviews and Reports] Scientists synthesize evidence on the genetic, environmental, and morphogenetic mechanisms associated with neural tube defects and evaluate the applications and limitations of human organoid and organoid-on-chip models in this field.

[Cell Stem Cell] Researchers established a patient-derived brainstem glioma organoid platform with high success. Multi-omics and functional assays revealed that diffuse midline gliomas maintain oligodendrocyte precursor cell (OPC) stemness by dysregulating ACTIVIN signaling.

[Cell Systems] The authors established an intestine-liver-tumor multi-organoid system to simulate in vivo absorption and metabolism, which allows for more physiologically relevant evaluations of drug efficacy and toxicity.

[Developmental Cell] Scientists generated elongating heart organoids from hiPSCs that undergo coordinated elongation and looping-like curvature, resembling early cardiac morphogenesis.

[Science Advances] Investigators showed that a DEAF1 mutation in hESCs disrupts chromatin accessibility at neuronal gene loci, leading to significant transcriptional alterations.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators demonstrated that the transition from a disordered mesenchymal state to a columnar epithelial structure in branched pancreatic ductal adenocarcinoma organoids is associated with rosette formation.