[JCI Insight] Scientists demonstrated that plasma growth differentiation factor 15 (GDF15) is elevated across diverse fibrotic lung disease subtypes and correlates with markers of elevated right heart pressures, but not pulmonary function indices, indicating a possible link to endothelial cell dysfunction.

[JCI Insight] Researchers identified alanine as an essential metabolite for myofibroblast differentiation. Transforming growth factor–β1 (TGF-β) increases intracellular alanine levels through enhanced synthesis and import in both normal and idiopathic pulmonary fibrosis lung fibroblasts.

[Journal of Medicinal Chemistry] The authors reported the discovery of NP12, the first SAMHD1 degrader with intracellular activity. In a bleomycin-induced pulmonary fibrosis mouse model, NP12 delayed pulmonary fibrosis progression and exerted a protective effect on lung tissue.

[American Journal of Respiratory Cell and Molecular Biology] Investigators demonstrated that the FAM13A long isoform is critical to patterning NKX2-1 + lung progenitor cells through dysregulating Wnt/β-catenin signaling during early stages of development in vitro.

[Archives of Toxicology] Scientists investigated the induction of the epithelial-mesenchymal transition of human bronchial epithelial cells BEAS-2B following six weeks of treatment with multi-walled carbon nanotubes ranging from 0.125 to 1 µg/cm².

[Proceedings of the National Academy of Sciences of the United States of America] Researchers developed an efficacious compound K (CK) derivative, CKD-4 with significantly enhanced cancer cell penetration and cytotoxicity both in vitro and in vivo.

[Journal of Translational Medicine] Scientists investigated whether lactate dehydrogenase C4 (LDHC4) promotes lung adenocarcinoma by modulating protein lactylation, a lactate-derived post-translational modification, focusing on the tumor suppressor retinoblastoma protein (RB1).

[iScience] The authors examines challenges, compare SIRT1's divergent roles, and evaluate chronotherapy, biomarker-guided selection, and SIRT1 activators.

[Nuvation Bio Inc. ] Nuvation Bio Inc. announced today that the US FDA has accepted a supplemental New Drug Application with updated data for IBTROZI^® (taletrectinib) in both TKI-naïve and TKI-pretreated advanced ROS1-positive NSCLC.

[Nature Materials] Researchers demonstrated that the formation of fibrillar adhesions locks the nucleus in a mechanically deformed conformation, setting the mechano-response timescale to that of fibrillar adhesion remodelling

[Journal of Nanobiotechnology] Scientists developed a 3D-printed tower-shaped microneedle system loaded with vitamin A-containing Bletilla striata vesicles for functionally staged effects supported by release kinetics in scarless wound healing.

[Particle and Fibre Toxicology] Researchers established epithelial Nlrp3/em> as a critical driver of silica-induced fibrotic remodeling through IL-18 and pro-fibrotic neutrophil recruitment, independent of canonical TGFβ mechanisms.