[Nature] Researchers showed that malignant cell states transcriptionally resemble stages of normal glial–neuronal lineage development or a reactive mesenchymal-like state, mirroring states previously described in isocitrate dehydrogenase (IDH) wild-type glioblastoma.

[Neuron] Investigators identified the histone acetyltransferase KAT7 as a central epigenetic regulator that links chromatin remodeling to mitochondrial immune activation.

[Nature Communications] Differential gene expression revealed that stiff matrices induce expression of IQ Motif Containing GTPase Activating Protein 3 (IQGAP3) through YAP1 and TEAD transcription factors in GBM stem cells.

[Nature Communications] The authors showed that CD31, a recognized endothelial marker, is predominantly expressed in microglia but not in neurons or astrocytes, and it is significantly elevated in the brains of Alzheimer’s disease patients and mouse models.

[Stem Cell Reports] Researchers found miR-151-5p is expressed in neural stem cells (NSCs) of the developing mouse cerebral cortex. Conditional knockout of miR-151-5p increased SOX2 expression in NSCs and enhanced their proliferative capacity.

[Scientific Reports] Scientists evaluated miR-219 effects on glioblastoma in vitro, in combination with radiation and temozolomide. They indicated that miR-219 may modulate tumor-related processes through the negative regulation of target genes such as REST and AKAP13.

[Trends in Cell Biology] Investigators focus particularly on astrocytes and integrate evidence from invertebrate models demonstrating that glial cells possess an intrinsic capacity for neurogenesis.

[Signal Transduction and Targeted Therapy] Scientists applied 3D patient-derived, metastatic human mammary organoids to model apoptosis resistance, necroptosis, and inflammatory signaling using single-cell CITE-sequencing, time-lapse live cell brightfield, and immunofluorescent confocal microscopy, as well as biochemical approaches.

[Cancer Research] Researchers revealed that commensal dysbiosis-associated loss of microbial bile acid (BA) metabolism elevates primary BAs and promotes HR+ metastatic progression through prostaglandin E2 signaling.

[Cancer Immunology Research] Using single-cell and spatial transcriptomes, investigators identified, at the single-cell level, a subpopulation of macrophages related to T cell expansion during immunotherapy, characterized by high expression of high-temperature requirement A1 (HTRA1), and correlated with clinical and immunotherapy outcomes in TNBC.

[Cell Death & Disease] The authors demonstrated that iroquois homeobox 1 (IRX1) is downregulated in breast cancer tissues and cell lines due to promoter hypermethylation.

[Journal of Nanobiotechnology] Scientists highlighted the potential of red blood cell-derived extracellular vesicles as a biocompatible delivery system enabling combined therapy and offering a promising strategy to overcome current limitations in TNBC treatment.