Keep Current with the Latest in Cell Biology Research
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Amide-Forming Ligations at Physiological Ph for the Encapsulation of Human Mesenchymal Stem Cells
[Biomacromolecules] Investigators demonstrated the construction of poly(ethylene glycol)-derived hydrogels by efficient cross-linking of quinolinium acyltrifluoroborate-functionalized macromers with a partner hydroxylamine-functionalized macromer.
MSCs Delivering LIGHT Prime Immune Response against CAFs to Harness Antigen Loss Variants
[Cancer Gene Therapy] The authors engineered MSCs to deliver the immuno-stimulatory TNF superfamily ligand LIGHT (MSC-L). They found that MSC-L simultaneously primed immune responses against both tumor cells and cancer-associated fibroblasts.
Human Bone Marrow Derived Mesenchymal Stem Cells Do Not Promote Oral Cancer Cell Growth In Vitro and Metastasis In Vivo
[Scientific Reports] Scientists assessed the effect of circulatory bone marrow derived-MSCs on proliferation, migration, invasion, tumor growth, and metastasis of oral squamous cell carcinoma cells.
Impact of Neoadjuvant Chemotherapy on the Functionality of Adipose-Derived Mesenchymal Stromal Cells and Their Modulatory Effects on Fibroblasts in Oncology Patients
[Scientific Reports] Researchers investigate the effects of chemotherapy on Adipose-derived-MSCs and their ability to influence fibroblast function in vitro.
Spatiotemporal Interplay Between Epithelial and Mesenchymal Cells Drives Human Dentinogenesis
[Nature Communications] DLX6-AS1+ dental pulp stem cells successfully generated tubular dentin in an in vivo disease model of dentin defects.
Human ES Cell-Derived MSC Spheroids Encapsulated in Polydopamine Nanoparticle-Modified GelMA Hydrogel Enhance Diabetic Wound Healing
[Journal of Nanobiotechnology] Researchers developed a composite bio-dressing by integrating MSC spheroid derived from human embryonic stem cells via trophoblast intermediates with gelatin methacryloyl hydroge and polydopamine nanoparticles.
Co-Delivery of Endometrial Mesenchymal Stem Cells and Macrophages by an Electrospun Patch Promotes Angiogenesis during Endometrial Injury Repair via VEGF Related Signalling
[Stem Cell Research & Therapy] Scientists developed a human endometrial MSCs-macrophages co-delivery system using an electrospun polycaprolactone-hyaluronic acid membrane and established a rat endometrial damage model.
Ultrasonically Targeted Destruction of SDF-1 Nanobubbles Carrying Mesenchymal Stem Cells Improves Renal Tubulointerstitial Fibrosis
[International Journal of Pharmaceutics] Researchers synthesized nanobubbles containing stromal cellÂ-derived factor 1 (SDFÂ1) and harvested MSCs from the bone marrow of SpragueÂDawley rats.
Long Term Cognitive Impairments Following Hypoxia-Induced Neonatal Seizure Restored by MSC-Derived Exosomes Injection: Role of Glutamatergic and GABAergic Receptors
[European Journal of Pharmacology] Investigators examined the therapeutic potential of MSC-derived exosomes in rat model of hypoxia-induced neonatal seizures.
Immune Checkpoint Inhibitor-Related Pneumonitis: Current Advances and the Putative Role of Mesenchymal Stem Cell Therapy
[Cell Death & Disease] The authors review recent advances in immune checkpoint inhibitor-related pneumonitis (ICIP) and propose the potential applications of MSC therapy, emphasizing the need for further research into its efficacy and safety to improve ICIP management.
Application Strategies of Bone Marrow Mesenchymal Stromal Cells in Bone-Related Diseases
[Cell Proliferation] Scientists summarize Bone marrow MSC-based treatment strategies for bone-related diseases, discuss current challenges, and outline future directions to advance translational research.
The Immunomodulatory Power of Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles in Bone Disorders: A Comprehensive Review
[Clinical and Experimental Medicine] Investigators summarize current knowledge on the biogenesis, composition, and characterization of MSC-derived extracellular vesicles, and then focus on how they modulate macrophages, neutrophils, T and B cells, natural killer cells, and other stromal populations in the bone microenvironment.

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