[Mount Sinai] Researchers at the Icahn School of Medicine at Mount Sinai will lead a new national clinical trial evaluating a precision medicine approach for infants with Noonan syndrome and related conditions who develop severe hypertrophic cardiomyopathy.

[Augusta University] Dr. Kunzhe Dong with the Immunology Center of Georgia, part of the Medical College of Georgia at Augusta University, has received a five-year, $3.8 million grant from the National Institutes of Health to study how a molecule in blood vessels may help protect against atherosclerosis.

[AFM-Telethon] AFM-Telethon is launching a two-year strategic research program with Drs. Drew Weissman and James Dowling. The aim is to develop lipid nanoparticles capable of targeting muscle tissue while minimizing uptake by the liver.

[Journal of Biochemical and Molecular Toxicology] Researchers hypothesized that PD-1 blockade–associated cardiotoxicity arises from a synergistic interaction between tumor cell secretory factors and immune checkpoint inhibition, culminating in ferroptotic cardiomyocyte death.

[Current Biology] Scientists investigated how cells shape and pack in 3D within a dense tissue with multiple cell types and spatiotemporally varying boundary constraints. They focused on the developing skeletal muscle in zebrafish.

[Cell Reports] Researchers demonstrated that exercise-induced exerkine clusterin mediates the pro-regenerative effects of running plasma on cardiac repair and cardiomyocyte proliferation following myocardial infarction.

[Cell Reports] Using patient-specific iPSC-derived cardiomyocytes and engineered heart tissues, the authors identified reduced survival motor neuron expression, mitochondrial respiratory defects, and impaired contractility in spinal muscular atrophy.

[Communications Biology] The authors evaluated the cardiogenic potential of satellite cells and mesenchymal progenitor cells from the masticatory muscle by reproducing, optimizing and diversifying previously described protocols.

[npj Biomedical Innovations] The authors address the role of delivery in overcoming challenges in cardiac adeno-associated viral therapies. Emphasis is placed on biomaterial-based delivery approaches to improve therapeutic outcomes.

[Nature Genetics] Investigators used genetic multiplexing to generate population-scale single-nucleus chromatin accessibility and transcriptome maps across 287 frozen human skeletal muscle biopsies. The results of this study illuminate the genetic regulatory architecture of human skeletal muscle.

[Nature] Using genetic and pharmacological tools, investigators demonstrated that lactate monocarboxylate transporter 1 (MCT1) is required for the oxidation of glucose carbon by mitochondrial pyruvate carrier-deficient myocardium.

[Circulation Research] Researchers investigated bromo adjacent homology domain coiled-coil 1 (BAHCC1) in human restenotic and atherosclerotic arteries and in rat and mouse arterial injury models using BAHCC1 silencing, smooth muscle cell-specific deletion, and an H3K27me3-binding-deficient knock-in mutation.