[Amphista Therapeutics Limited] Amphista Therapeutics Limited announced dosing of the first patient in a Phase I trial for its lead candidate, AMX-883, investigating the safety, pharmacokinetics, and preliminary efficacy in participants with acute myeloid leukemia and high-risk myelodysplastic syndrome.

[Nature Chemical Biology] The authors demonstrated that the efficacy of QC6352 and its clinical analog zavondemstat are independent of histone lysine demethylase 4 (KDM4) inhibition using comprehensive chemical biology approaches in glioblastoma models.

[EMBO Molecular Medicine] Researchers showed that disruption of the Wnt-antagonist and tumor suppressor adenomatous polyposis coli (Apc) leads to pituitary tumors that present all classic molecular and histopathological hallmarks of adamantinomatous craniopharyngiomas.

[Cancer Letters] Scientists explored a reactive oxygen species-based strategy as a new tool to isolate stem cells transcending traditional markers, and identified novel clinically relevant vulnerabilities to target leukemia stem cells.

[Cancer Letters] Through multi-omics analyses of hepatocellular carcinoma cohorts, investigators identified heterogeneous nuclear ribonucleoprotein C (HNRNPC) as a pivotal driver of a high-risk molecular subtype.

[EMBO Reports] Researchers integrated single-cell RNA sequencing datasets and discovered the specific enrichment of the long noncoding RNA Carmn in epithelial stem cell-enriched basal lineages. They showed Carmn is required for tumor formation by Wnt1-driven tumor stem cells.

[Cancer Cell International] The authors highlighted the catastrophic potential of atypical fusion processes, wherein widespread and large-scale genomic changes can occur at a rapid macroevolutionary pace and potentiate the risk for subclonal heterogeneity and malignancy.

[Scientific Reports] Scientists identified G protein subunit gamma transducin 1 (GNGT1) as a clinically relevant oncogenic driver that promotes gastric cancer growth, stemness, and metastatic traits.

[Medical Oncology] Investigators provided novel insights into the mechanisms underlying cigarette smoke-induced bladder cancer and highlighted the potential of exosomal circ55033 as a preliminary candidate diagnostic and therapy biomarker.

[Brain Research Bulletin] The authors aimed to identify key glioma stem cell–endothelial transdifferentiation-associated genes and develop a personalized prognostic framework integrating molecular and clinical factors.

[Journal of Natural Medicines] Researchers evaluated the antiproliferative activity of panduratin A against U-251 MG glioblastoma cells and U-251 MG CSCs and found that it exhibited potent activity against both cell populations.

[Nature Cancer] Scientists provide an overview of nongenetic plasticity mechanisms and their emerging clinical applications in cancer therapy.