[IJC] The Josep Carreras Leukemia Research Institute (IJC) has welcomed a high-level delegation from the Institute of Hematology & Blood Diseases Hospital. Collaborative efforts will address critical challenges in the field, including the biology of blood cancer stem cells, mechanisms of therapeutic resistance, and the development of next-generation immunotherapies.

[Oncogene] Scientists demonstrate that the ATP-binding cassette transporter A3 (ABCA3) maintains lipid metabolic balance in glioblastoma stem cells. Knocking down ABCA3 significantly reduces cell growth, self-renewal, viability, and tumor growth after intracranial implantation.

[Cell Death & Disease] Researchers identified Integrin subunit alpha-3 (ITGA3) as a key driver of circulating tumor cell generation and metastatic progression in pancreatic ductal adenocarcinoma. ITGA3 promotes epithelial–mesenchymal transition, enhances matrix metalloproteinase expression, and facilitates tumor cell detachment.

[BMC Cancer] The authors develooped a therapeutic colorectal cancer stem cell-based vaccine to explore whether this vaccination could inhibit the formation and prolong survival rates in a mouse model of colorectal cancer.

[NPJ Breast Cancer] Using POU1F1-overexpressing and knock-down breast cancer cell lines, as well as immunodeficient mouse models, the data demonstrated that POU1F1 induces a breast cancer stem cell-like phenotype in breast tumor cells by deregulating markers such as CD24, CD44, CD133, and ALDH.

[ACS Chemical Biology] Investigators established the first proof of concept for light-controlled autophagy inhibition and provide a blueprint for spatiotemporally confined anticancer therapies based on photopharmacological modulation of cancer stem cells.

[Nature Communications] Researchers found that SOAT1 is selectively expressed in CSC and pharmacological inhibition with STK results in robust anti-tumor effects across various preclinical mouse models, including colon, liver, lung, breast, and melanoma cancer, with low toxicity.

[Cancer Cell International] Scientists summarize the evidence indicating that cancer originates and progresses under the action and influence of specific factors and mechanisms that regulate, in a finely way, tumor cell growth and dissemination.

[Molecular Oncology] The authors summarize the regulation of the Hippo pathway, emphasizing its significant role in coordinating stemness-related mechanisms in breast cancer.

[Cyclerion Therapeutics, Inc.] Cyclerion Therapeutics, Inc. and Korsana Biosciences, Inc., announced that they have entered into a definitive merger agreement for an all-stock transaction.

[Signal Transduction and Targeted Therapy] The authors found that Bmp4 produced by late-stage oligodendrocyte precursor cells, termed committed oligodendrocyte precursors, acts as a critical signal shaping microglial neuroprotective programs in the context of amyloid pathology.

[Nature Neuroscience] Through multi-omic analyses of iPSC-derived neurons harboring disease-associated Ubiquilin 2 (UBQLN2) mutations, researchers uncovered UBQLN2 as a molecular hub linking lipid dysregulation and proteostasis, the perturbation of which contributes to neurodegeneration.