[UCLA Health] UCLA researchers Drs. Jason Chiang and Kyung Sung were awarded a $3.2 million NCI grant to develop AI-driven imaging technology for improved Y90 treatment planning in liver cancer.

[Molecular Cancer] Scientists identified a complex network of immune suppression and lipid metabolic reprogramming that contributes to immunotherapy resistance in liver cancer.

[Nature Genetics] Researchers mapped chromatin accessibility in human MASLD liver nuclei, revealing enrichment of risk variants within cell-type-specific regulatory elements bound by lineage-determining transcription factors.

[Signal Transduction and Targeted Therapy] Investigators reported that fructose suppresses HCC through fructose 1-phosphate-mediated inhibition of mannose phosphate isomerase in the context of fructose-1,6-bisphosphate aldolase B deficiency.

[Science Translational Medicine] Using single-cell RNA sequencing and spatial transcriptomics of tissues of patients with CCA, researchers showed that CLDN1 expression is up-regulated in cancer cells and is associated with stemness and cell fate.

[Elife] Scientists sought to elucidate the metabolic basis of Kupffer cell (KC) death during metabolic dysfunction-associated steatotic liver disease (MASLD). Using metabolomics, immunostaining, and flow cytometry, they evaluated metabolic alterations and KC death throughout early MASLD progression.

[Cell Death Discovery] The authors explored the mechanisms of epithelial HCC cells (EC) acquire resistance to ferroptosis. Transcriptomics and metabolomics analyses revealed that the cysteine and methionine metabolic pathway is associated with the resistance of EC to ferroptosis inducer imidazole ketone erastin.

[Scientific Reports] Researchers found that the m⁶A modification sites are highly abundant on UNC5B-AS1, and methylase WT1-associated protein enhances UNC5B-AS1 stability through m6A reader-YTHDF1 and up-regulates its expression in HCC.

[Circulation Research] Scientists explore a deeper understanding of hepatic lipid and lipoprotein homeostasis in MASLD for several reasons connected with some of the molecular and signaling adaptations occurring in obesity and type 2 diabetes.

[Hepatology Communications] The authors discuss recent findings related to neutrophil extracellular traps in inflammatory and fibrotic liver diseases as well as liver cancer.

[Respiratory Research] Researchers integrated single-cell transcriptomics, conditional gene knockout mouse models, organoid culture, multiplex immunofluorescence validation, and flow cytometry to investigate the role of the RS1 gene in chronic obstructive pulmonary disease.

[Transplantation] Investigators reported a novel cold storage ischemia/reperfusion injury model that incorporates physiological flow, stretch, and cell-cell interactions.