[Gut] Scientists investigated the role of the oxidative stress sensor protein Pirin as a critical mediator of inflammation in hepatocellular carcinoma progression.

[Gut] Researchers elucidated the role of Selenoprotein P-mediated selenium metabolism in driving the accumulation and immunosuppressive function of senescent-like neutrophils in HCC.

[Science Advances] Using an integrative approach combining transcriptomics, ribosome profiling, cytoplasmic polyadenylation analysis, and cis-regulatory mapping, investigators defined the posttranscriptional landscape induced by chronic high-fat diet exposure.

[Cell & Bioscience] Researchers generated doxycycline-inducible expression systems to upregulate One Cut Homeobox 1 (ONECUT1) in hepatoblastoma cells in culture and in mouse models.

[British Journal of Cancer] The authors explored the molecular mechanism by which LRRC41 promotes HCC malignancy and investigated the therapeutic potential of inhibiting its mediated signalling pathway.

[Oncogene] Scientists constructed a patient-derived xenograft model of HCC to compare and analyze the tumor tissues of the immunotherapy responder group and the non-responder group.

[Inflammation] To elucidate the specific role of interleukin-25 (IL-25), hepatocyte-specific IL-25 conditional knockout mice were generated using CRISPR/Cas9 technology and subjected to the liver fibrosis model.

[Hepatobiliary & Pancreatic Diseases International] Scientists introducedthe application of organoids in liver diseases, and focused on viral hepatitis, primary liver cancer, and non-alcoholic fatty liver disease due to their high prevalence and the maturity of organoids in these areas.

[CatalYm] CatalYm announced that the first patient has been dosed in the GDFATHER-HCC-01 trial. The Phase IIb trial targets patients who have progressed following 1L treatment with an anti-PD-(L)1-based therapy.

[Nature Communications] Researchers employed cell lineage tracing, targeted cell ablation, and single-cell RNA sequencing to monitor fibroblast dynamics upon exposure to Aspergillus fumigatus in immunocompetent and immunosuppressed hosts.

[Journal of Medicinal Chemistry] Scientists reported the discovery of NP12, the first SAMHD1 degrader with intracellular activity. In a bleomycin-induced pulmonary fibrosis mouse model, NP12 delayed pulmonary fibrosis progression and exerted a protective effect on lung tissue.

[Signal Transduction and Targeted Therapy] Investigators revealed that the BMX (bone marrow tyrosine kinase on chromosome X)-E2F1 (E2F transcription factor 1) axis is a pivotal regulator of chemoresistance in small cell lung cancer.