Intestinal Cell News

Intestinal Cell News is an online resource that curates the latest research using intestinal cells.

$2M to Better Understand and Prevent Colorectal Cancer

March 20, 2026

[Université de Montréal] Université de Montréal epidemiologist Vikki Ho has been awarded a $2-million grant over five years to study how environmental and other factors contribute to the onset of colorectal cancer.

ADAT2-Mediated a-to-I tRNA Modification Promotes Oncogenic Translation and Colorectal Cancer Progression and Chemoresistance

March 20, 2026

[Molecular Cancer] Researchers found that adenosine deaminase tRNA specific 2 (ADAT2)-driven tRNA A-to-I modification promotes colorectal cancer tumorigenesis and chemoresistance via HDAC7-WNT/β-catenin axis.

Frazzled/DCC Directs Spatial Progenitor Integration Ensuring Steady-State Intestinal Turnover

March 20, 2026

[Nature Communications] Scientists showed that a conserved axonal guidance cue directs enteroblasts, the immediate intestinal stem cell daughters, to selectively replace worn-out adjacent and remote enterocytes with identical frequency.

PI3K and MAPK Signaling Nodes Serve As Divergent Drivers of Phenotypic Plasticity in Cancer-Associated Fibroblasts in Colorectal Cancer

March 20, 2026

[Cancer Research] Investigators identified that the PI3K/mTOR and MAPK/ERK signaling pathways, among other pathways, are linked to the formation of myofibroblast-like cancer-associated fibroblast (CAF) and inflammatory CAF subtypes, respectively.

AI-Enabled Single-Cell Dissection of the Palmitoylation Landscape Identifies a Multicellular Prognostic Program in Gastric Cancer

March 20, 2026

[NPJ Precision Oncology] Researchers integrated single-cell RNA sequencing, 119,931 cells from 25 gastric tumors, with spatial transcriptomics and bulk cohorts to delineate palmitoylation-linked states across malignant, immune, and stromal compartments.

Dissecting the Differentiation Origins of Intestinal Metaplasia and Early Intestinal-Type Gastric Cancer in Gastric Antrum by Single-Cell RNA Profiling

March 20, 2026

[NPJ Precision Oncology] The authors analyzed the differentiation trajectory of epithelial cells in different disease stages from gastric antrum biopsies in patients with precancerous lesions and early gastric cancer using single-cell sequencing data.

Cathepsin E Drives Colorectal Cancer Progression and Immune Evasion via ZNF326 ADP-Ribosylation and TGF-β/SMAD Activation

March 20, 2026

[Journal of Translational Medicine] Researchers found that cathepsin E drives colorectal cancer progression by stabilizing ZNF326 via ADP-ribosylation and activating TGF-β/SMAD pathway, while facilitating tumor immune evasion.

Colorectal Cancer Pathogenesis, Oncogenic Signaling Networks, and Targeted Therapeutic Advances

March 20, 2026

[Molecular Biomedicine] Investigators delineate the core signaling cascades governing colorectal cancer initiation and progression, with emphasis on the molecular hallmarks of the disease.

US FDA Grants Full Approval to Pfizer’s BRAFTOVI Combination Regimen in First-Line Metastatic Colorectal Cancer

March 6, 2026

[Pfizer Inc. ] Pfizer Inc., announced that the US FDA has granted full approval to BRAFTOVI^® in combination with cetuximab and fluorouracil-based chemotherapy for the treatment of adult patients with metastatic colorectal cancer with a BRAF V600E mutation based on results from the global Phase III BREAKWATER trial.

Five Global Teams Awarded $125 Million to Take on the Toughest Challenges at the Frontiers of Cancer Science

March 6, 2026

[Cancer Grand Challenges (Business Wire)] Cancer Grand Challenges, a global initiative co-founded by the National Cancer Institute in the US and Cancer Research UK, announced a major $125m commitment to propel cancer research into uncharted territory.

Villification of the Intestinal Epithelium Is Driven by Foxl1 through Activation of PDGFRα and BMPs

March 6, 2026

[Nature Communications] Investigators set out to determine the molecular targets and pathways controlled by Foxl1 during intestinal villification

Systematic Analysis of Functional Genetic and Epigenetic Variants in Colorectal Cancer

March 6, 2026

[Science Advances] Scientists adapted and applied two high-throughput techniques, SNP-STARR-seq and Methyl-STARR-seq, to systematically evaluate the influence of 30,790 noncoding SNPs and more than 134,000 CpG sites on enhancer activity in primary and metastatic CRC cells.

Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.