 | | Vol. 7.09 – 15 March, 2021 |
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Researchers report a versatile prodrug nanoparticle for second near‐infrared florescence imaging‐guided combinatory immunotherapy of colorectal cancer.
[Small] |
|  | | PUBLICATIONSRanked by the impact factor of the journal |
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| Effects of intestinal epithelial cells transfected with metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) lentiviruses and Smart Silencer, on monolayer permeability and apical junction complex proteins were analyzed.
[Journal of Crohns & Colitis] |
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| Mechanistically, plectin deficiency in intestinal epithelial cell led to aberrant keratin filament network organization and the formation of dysfunctional hemidesmosomes and intercellular junctions.
[Mucosal Immunology] |
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| Investigators describe results with a new anti-cancer small molecule, WEHI-7326, which caused cell cycle arrest in G2/M, cell death in vitro, and displayed efficacious anti-tumor activity in vivo.
[Cell Death & Disease] |
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| Researchers conducted a phosphoproteomic analysis of diffuse-type gastric carcinoma cells possessing Met gene amplification and identified Pleckstrin Homology Domain Containing A5 (PLEKHA5) as a protein that is tyrosine-phosphorylated downstream of Met.
[Oncogenesis] |
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| Scientists cocultured human-induced pluripotent stem cell-derived intestinal cells and fresh human hepatocytes which were isolated from PXB mice with medium circulation in a pneumatic-pressure-driven microphysiological systems with pipette-friendly liquid-handling options.
[Scientific Reports] |
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| The authors report a robust protocol for the isolation, maintenance and differentiation of rabbit small intestinal organoids and organoid-derived cell monolayers.
[Scientific Reports] |
| | To test the interaction between AGAP2-AS1 and LINC-PINT in colon cancer, overexpression vector or inhibitor of AGAP2-AS1 and LINC-PINT were transfected into RKO and HCT 116 cells.
[Cancer Management and Research] |
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| Scientists review how Parkinson’s disease and Crohn’s disease share overlapping phenotypes, particularly in terms of leucine-rich repeat kinase 2 (LRRK2) in the context of the immune system, that could be targeted in future therapies.
[npj Parkinson’s Disease] |
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| The authors summarize the signaling pathways contributing to intestinal cell fates and homeostasis functions, focusing on intestinal stem cell proliferation, cell junction formation, remodeling, hypoxia, the impact of intestinal microbiota, the immune system, inflammation, and metabolism.
[Cell Communication and Signaling] |
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| Unfortunately, most of the newly designed metal-based complexes exhibit lack of selectivity against cancer cells, low solubility and permeability, high dose-limiting toxicity, and emergence of resistances. Nanodelivery systems enable the incorporation of metallodrugs at adequate payloads, solving the above-referred drawbacks.
[Drug Delivery and Translational Research] |
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| Canadian Science Publishing announced a new transformative open access publishing agreement with the University of California (UC) that will offer unlimited open access publication for UC researchers publishing with its journals.
[Canadian Science Publishing] |
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| Long Island Jewish (LIJ) Medical Center, in collaboration with the Northwell Health Cancer Institute, is testing the efficacy of delivering aerosolized chemotherapy to patients who currently have few treatment options, the second such clinical trial site in the nation.
[Long Island Jewish (LIJ) Medical Center] |
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| October 7 – 11, 2021
Virtual |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | Wellcome Trust Sanger Institute – Cambridge, England, United Kingdom |
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| | AMOLF – Amsterdam, Netherlands |
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| | Duke University – Durham, North Carolina, United States |
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| | Institut Pasteur of Shanghai, Chinese Academy of Sciences – Shanghai, China |
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Cancer Stem Cell News
Cell Therapy News
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Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
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Pancreatic Cell News
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