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Intestinal Cell News
Intestinal Cell News is an online resource that curates the latest research using intestinal cells.
NEDD4L Mediates Intestinal Epithelial Cell Ferroptosis to Restrict Inflammatory Bowel Diseases and Colorectal Tumorigenesis
[Journal of Clinical Investigation] NEDD4L expression was significantly inhibited in intestinal epithelial cells (IECs) of patients with Crohn's disease, ulcerative colitis, and colorectal cancer. Global knockout of NEDD4L or its deficiency in IECs exacerbated dextran sulfate sodium (DSS)-/2,4,6-trinitrobenzene sulfonic acid-induced colitis and azoxymethane/DSS-induced colorectal cancer.
Neoadjuvant Modified Infusional Fluorouracil, Leucovorin, and Oxaliplatin with or without Radiation Versus Fluorouracil plus Radiation for Locally Advanced Rectal Cancer: Updated Results of the...
[Journal of Clinical Oncology] Researchers presented 10-year results of the Phase III FOWARC trial, which evaluated the efficacy of modified infusional fluorouracil, leucovorin, and oxaliplatin with or without radiation compared with fluorouracil with radiation in patients with locally advanced rectal cancer.
Addition of SHR-1701 to First-Line Capecitabine and Oxaliplatin (XELOX) plus Bevacizumab for Unresectable Metastatic Colorectal Cancer
[Signal Transduction and Targeted Therapy] This Phase II/III trial assessed the efficacy and safety of SHR-1701, a bifunctional protein targeting PD-L1 and TGF-β, in combination with BP102 XELOX as a first-line treatment for unresectable metastatic colorectal cancer.
DRD4 Interacts with TGF-β Receptors to Drive Colorectal Cancer Metastasis Independently of Dopamine Signaling Pathway
[Advanced Science] Scientists investigated the expression and function of dopamine receptor D4 (DRD4) in colorectal cancer (CRC) and elucidated the DRD4-regulated signaling pathway in CRC metastasis.
Fusobacterium nucleatum Promotes Colorectal Cancer through Neogenesis of Tumor Stem Cells
[Journal of Clinical Investigation] Investigators uncovered that F. nucleatum colonized the depths of gut crypts in both human colorectal cancer patients and mouse models.
Integration of Lipidomics with Targeted, Single Cell, and Spatial Transcriptomics Defines an Unresolved Pro-Inflammatory State in Colon Cancer
[Gut] The authors explored if lipid dysregulation in colorectal cancers was driven by a failure to resolve inflammation.
Long-Term Outcomes of an Infliximab-First Versus Vedolizumab-First Treatment Strategy in Biologic-Naïve Patients With Ulcerative Colitis
[Alimentary Pharmacology & Therapeutics] Researchers compared infliximab-first and vedolizumab-first strategies in biologic-naïve patients with ulcerative colitis.
Intestinal Mucus Barrier: A Potential Therapeutic Target for IBD
[Autoimmunity Reviews] Scientists highlighted the important role of the mucus layer in inflammatory bowel disease (IBD) and the therapies that target the mucus layer in IBD.
Bowel Cancer Is Rising in Younger People Around the World
[NewScientist] More and more people under 50 have been diagnosed with bowel cancer in different parts of the world over the past few decades.
Potential Therapeutic Strategies for Colitis and Colon Cancer: Bidirectional Targeting STING Pathway
[eBioMedicine] The authors provide a comprehensive overview of STING inhibitors/agonists that have been systematically evaluated in the contexts of colitis and colon cancer and their specific molecular mechanisms.
LGALS9B Stabilizes EEF1D Protein and Activates the PI3K/AKT Signaling Pathway to Promote Gastric Cancer Occurrence and Metastasis
[Oncogene] Researchers investigated the role of galectin-9B (LGALS9B) in gastric cancer progression, demonstrating that its over-expression enhanced cellular proliferation, migration, and invasion, while its knockdown inhibited these processes both in vitro and in vivo.
The Mesenteric Adipokine SFRP5 Alleviated Intestinal Epithelial Apoptosis Improving Barrier Dysfunction in Crohn’s Disease
[iScience] Researchers analyzed the expression of secreted frizzled-related protein 5 (SFRP5), a adipokine with cytoprotective effects, in hypertrophic mesenteric adipose tissue and its role in Crohn's disease.
Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.
