Mutation in the CCAL1 Locus Accounts for Bidirectional Process of Human Subchondral Bone Turnover and Cartilage Mineralization

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OPG-XL was studied by human induced pluripotent stem cells expressing OPG-XL and two isogenic CRISPR/Cas9-corrected controls in cartilage and bone organoids.
[Rheumatology]

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Abstract