Loss of KMT5C Promotes EGFR Inhibitor Resistance in NSCLC via LINC01510-Mediated Upregulation of MET

Researchers identified that loss of an epigenetic factor, lysine methyltransferase 5C (KMT5C), drove resistance of NSCLC to multiple EGFR inhibitors, including erlotinib, gefitinib, afatinib, and osimertinib.