Mouse and Human Antibodies Bind HLA-E-Leader Peptide Complexes and Enhance NK Cell Cytotoxicity

Researchers reported the isolation of 3H4, a murine human leukocyte antigen E (HLA-E)-VL9-specific IgM antibody that enhanced killing of HLA-E-VL9-expressing cells by an NKG2A⁺ NK cell line.