DNA Methylation Maintenance at the p53 Locus Initiates Biliary-Mediated Liver Regeneration

The authors showed that in response to extensive hepatocyte damages, expression of dnmt1 was upregulated in biliary epithelial cells (BECs) to methylate DNA at the p53 locus, which repressed p53 transcription, and in turn, derepressed mTORC1 signaling to activate BEC dedifferentiation.