Ultraviolet Light Induces HERV Expression to Activate RIG-I Signaling Pathway in Keratinocytes

UVB-induced human endogenous retrovirus (HERV)-associated double-stranded RNA transcription and subsequent activation of the innate antiviral retinoic acid-inducible gene I(RIG-I)/MDA5/IRF7 pathway led to downstream transcription of interferon-stimulated genes, which promotes UVB-induced apoptosis and proliferation inhibition in keratinocytes