Robo4 Is Constitutively Shed by ADAMs from Endothelial Cells and the Shed Robo4 Functions to Inhibit Slit3-Induced Angiogenesis

Researchers reported soluble Robo4 was the product of constitutive ectodomain shedding of endothelial cell surface Robo4 by disintegrin metalloproteinases ADAM10 and ADAM17 and acted to inhibit angiogenic Slit3 signaling.