Clock-Modified Mesenchymal Stromal Cells Therapy Rescues Molecular Circadian Oscillation and Age-Related Bone Loss via miR142-3p/Bmal1/YAP Signaling Axis

Proliferation capability, osteogenic lineage commitment, senescence-associated secreted phenotype and circadian oscillation of clock genes under osteogenic condition were assessed in bone marrow MSCs from young adult and aged adult mice.