Exosomes Derived from Bone Mesenchymal Stem Cells Attenuate Myocardial Fibrosis Both In Vivo and In Vitro via Autophagy Activation: The Key Role of miR-199a-3p/mTOR Pathway

Scientists investigated the antifibrosis effects of exosomes by focusing on miRNAs. Myocardial fibrosis was induced in rats using transverse aortic constriction method and handled with exosomes from bone MSCs.