Review

[Journal of Experimental & Clinical Cancer Research] Although anti-tumorigenic properties of cancer-associated fibroblasts (CAFs) have been reported, the majority of research demonstrates a pro-tumorigenic role for CAFs via (in)direct signaling to cancer cells, immunomodulation and ECM remodeling.

[Signal Transduction and Targeted Therapy] Cilia, the ECM, epigenetic modifications, and hypoxia conditions play important roles in cardiac development. These factors play crucial roles at one or even multiple stages of cardiac development.

[Trends In Molecular Medicine] The authors describe translational regulation in fibrosis and highlight a model where a conserved evolutionary mechanism may explain this regulation.

[Biofabrication] Advances in 3D bioprinting have allowed the creation of more complex models with improved physiologic representation while controlling for reproducibility and accuracy. The authors discuss the advantages and challenges of current 3D in vitro models for evaluating therapy response in breast cancer.

[Cell Communication and Signaling] Researchers examine the molecular architecture and composition of various types of inflammasomes, highlighting their activation and effector mechanisms within the context of the HSCT process and its associated complications.

[NPJ Precision Oncology] Scientists discuss the landscape of clinical trials for CAR-T cell therapy targeting brain tumors, highlighting key advancements like novel target antigens and combinatorial strategies designed to address tumor heterogeneity and immunosuppression.