Publication

[Cell & Bioscience] After 8-days treatment of TGF-beta following by bFGF, cells entered into epithelium-mesenchymal transition and gave rise to smooth muscle cells. Epicardium could also integrate and invade into mouse heart with SNAI1 expression, and give birth to numerous cardiomyocyte-like cells.

[Journal of Clinical Investigation] Investigators showed that the cysteine proteome of skeletal muscle functioned as a redox buffer in wild-type and murine dystrophin-deficient (mdx)muscle during eccentric contractions, but the buffer capacity in mdx muscle was significantly compromised by elevated basal protein oxidation.

[Journal of Muscle Research and Cell Motility] To better understand the role of MEGF10 in satellite cells, investigators overexpressed human multiple EGF domain protein 10 (MEGF10) in mouse H-2kb-tsA58 myoblasts and found that it inhibited fusion.

[Journal of Clinical Investigation] Administering monoclonal antibodies to respectively neutralize TNF-α and IGF1 produced by CX3CR1+ cells from Marfan Syndrome (MFS) patients greatly suppressed the cocultured MFS patient-specific induced pluripotent stem cell-derived vascular smooth muscle cell inflammation.

[International Journal of Biological Macromolecules] Scientists revealed that hypoxia downregulated circCCNL2 expression, and overexpression of circCCNL2 attenuated pulmonary hypertension progression and inhibited the proliferation of pulmonary artery smooth muscle cell.

[Cell Communication and Signaling] Researchers explored the effect of endogenous H2S/cystathionine γ-lyase pathway on the endothelin-1/endothelin type A receptor binding and its underlying mechanisms in the cellular and animal models of pulmonary arterial smooth muscle cell proliferation.