Publication

[Cancer Research] Researchers demonstrated that age engendered the development of an immunosuppressive tumor microenvironment, which was linked to phenotypes associated with melanoma metastasis. TREM1 inhibition decreased melanoma growth in young but not old mice, whereas TREM2 inhibition prevented lung metastasis in aged mice.

[Advanced Healthcare Materials] Cell differentiation was reported using a spatial geometric platform that could periodically modulate complex mechanical forces through a custom-made soft pneumatic device to mimic the interfaces between periosteum and interstitial fluid.

[Proceedings of The National Academy of Sciences of The United States of America] Investigators demonstrated that tryptophan-aspartic acid (WD) repeat protein 5 (Wdr5)-mediated H3K4 methylation was crucial for maintaining genomic stability of proliferating hematopoietic stem and progenitor cells in zebrafish embryos.

[Advanced Science] An integrated analysis identified collagen type I alpha 1 chain as a major component of the ECM that contributed to chemoresistance and poor prognosis, highlighting its potential as a therapeutic target.

[Nature Communications] Scientists demonstrated an approach that combined lipid-enriched maturation medium with a high concentration of calcium, nanopatterning of culture surfaces, and electrostimulation to generate hiPSC-derived cardiomyocytes with advanced electrophysiological, structural and metabolic phenotypes.

[Advanced Science] The authors conducted the first genome-wide identification of silencers in the mouse genome. In mouse embryonic fibroblasts and mESCs, 89 596 and 115 165 silencers were identified, respectively.