Publication

[HemaSphere] Scientists developed a novel in vitro 3D lymph node-like spheroid model of the leukemic microenvironment by culturing human chronic lymphocytic leukemia cells with fibroblastic reticular cells

[Journal of Cell Biology] Scientists identified downregulation of genes related to cell–ECM interactions and TGFβ signaling in FPRMS, and confirmed that TGFβ signaling enhances cell–ECM interactions in FNRMS.

[Cancer Science] Researchers demonstrated that the Hippo pathway-associated kinases, LATS1/2, in cancer cells are essential for collective force generation and fibroblast activation via ECM-mediated cell–cell interactions.

[Chinese Medical Journal] Researchers characterized the immune microenvironment of a newly identified secondary tumor post-CAR-T therapy, to clarify its pathogenesis and potential therapeutic targets.

[ACS Nano] Scientists developed a premetastatic niche-targeted nanodrug by coating programmed cell death protein 1 (PD-1)-high expressed T cell membranes on the surface of STING activator 2′3′-cGAMP-loaded PLGA@MnO2 nanoparticles (PSMP) for suppressing metastatic LUAD.

[EMBO Reports] Analysis of human lung adenocarcinoma and murine models revealed that cancer cells display heterogeneous YAP/TAZ activation levels within tumors. Murine lung cancer cells with high YAP/TAZ activity grow rapidly but are sensitive to ferroptosis, a cell death induced by lipid peroxidation.