Publication

[Journal of Experimental Medicine] Scientists reported that transcriptional repressor REV-ERB was critical for the differentiation and function of colonic RORγt+Foxp3+ Treg cells.

[JCI Insight] Scientists demonstrate that knocking down or inhibiting HDAC8 impaired murine Treg suppressive function in vitro and in vivo, but promoted conventional host T cell responses, thereby limiting syngeneic tumor growth.

[Science Translational Medicine] Scientists showed that ubiquitin-proteasome system disruption in alveolar type 2 epithelial cells amplifies profibrotic signaling to macrophages through macrophage migration inhibitory factor family proteins in several models.

[Molecular Therapy] Researchers identified circPTK2, a fibroblast-specific circular RNA that is significantly upregulated in pulmonary fibrosis patients and experimental models.

[Scientific Reports] Investigators presented a comprehensive workflow for the isolation and culture of primary human AT2 cells, including an efficient enzyme-based lung tissue digestion protocol and automated purification of human alveolar type 2 cells from both healthy and diseased lungs.

[Scientific Reports] The authors investigated the impact of KDM6B on macrophage processes during sepsis-induced acute lung injury and elucidated the underlying molecular mechanisms.