Publication

[Advanced Materials] The hypothesis that matrix viscoelasticity regulates vascular development was investigated in 3D cultures by encapsulating blood vessel organoids within viscoelastic gelatin/β-CD assembly dynamic hydrogels or methacryloyl gelatin non-dynamic hydrogels.

[Nature Communications] Researchers found that Collagen I expression was commonly upregulated in adult basal stem cells (BaSCs) across the different multipotent conditions. Increasing collagen concentration or stiffness of the ECM promoted BaSC multipotency in mammary gland and prostate organoids.

[Signal Transduction and Targeted Therapy] The randomized Phase III CHART trial revealed that rezvilutamide plus androgen deprivation therapy in high-volume, metastatic, hormone-sensitive prostate cancer significantly enhanced radiographic progression-free and overall survival than bicalutamide.

[Journal of Clinical Investigation] NEDD4L expression was significantly inhibited in intestinal epithelial cells (IECs) of patients with Crohn's disease, ulcerative colitis, and colorectal cancer. Global knockout of NEDD4L or its deficiency in IECs exacerbated dextran sulfate sodium (DSS)-/2,4,6-trinitrobenzene sulfonic acid-induced colitis and azoxymethane/DSS-induced colorectal cancer.

[Development] Scientists investigated how levels of ASCL1 and its phosphorylation modulated its activity over progressive lineage restriction of mouse embryonic stem cells.

[Journal of Clinical Investigation] Upon induction of Ecotropic viral integration site 1 (Evi1) expression, mice displayed anemia, thrombocytopenia, lymphopenia, and erythroid and megakaryocyte dysplasia with a significant expansion of committed myeloid progenitor cells, resembling human myelodysplastic syndrome/myeloproliferative neoplasm–like disease.