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[Blood] Leveraging a Phase I clinical trial of the gamma-secretase inhibitor, crenigacestat, with anti-BCMA CAR T cells, researchers utilized single-nuclei RNA sequencing and Assay for Transposase-Accessible Chromatin sequencing to characterize the effects of gamma-secretase inhibitor on the tumor microenvironment.

[Cancer Discovery] Investigators present a detailed examination of the epigenetic hallmarks affected in human cancer, elucidating the pathways and genes involved, and dissecting the disrupted landscapes for DNA methylation, histone modifications, and chromatin architecture that define the disease.

[Scientific Reports] Researchers performed the next-generation sequencing analysis of gastrocnemius muscles from immobilized versus non-mobilized legs.

[Acta Pharmacologica Sinica] The authors investigated whether zonisamide prevented pressure overload-caused myocardial hypertrophy through suppressing proteasome.

[Acta Pharmacologica Sinica] Scientists investigated the role of CCL2 in cardiac regeneration and the underlying mechanisms. Myocardial infarction was induced in adult mice by permanent ligation of the left anterior descending artery.

[Circulation Research] Protein interaction was determined by immunoprecipitation assay in primary cardiomyocytes and mouse cardiac samples subjected or not to transverse aortic constriction for one week.