TNF-α

[Cell Death & Disease] Scientists evaluated the anti-inflammatory effects and potential mechanisms of action of 3TC in vitro in retinal microvascular endothelial cells treated with high-glucose and lipopolysaccharide.

[PLoS One] Investigators embedded a scaffold material containing conditioned medium of MSCs (MSC-CM) pretreated with IFN-γ and TNF-α and reconfirmed that cell migration and activation were superior to that in the presence of MSC-CM in vivo.

[Cell Reports] Scientists revealed that the abrogation of tolerogenic functions during an acute immunogenic maturation depended on an ablation of the tolerogenic conventional dendritic cell (cDC) population, resulting in a dynamic remodeling of the cDC functional landscape.

[Experimental & Molecular Medicine] Scientists suggested that inflammatory mediators in synovial fluid, including TNF-α, recruited sodium bicarbonate cotransporter n1 (NBCn1) to the plasma membrane of fibroblast-like synoviocytes to provide dynamic properties and that modulation of NBCn1 could be developed into a therapeutic strategy for rheumatoid arthritis.

[Cell Reports] Scientists revealed that the abrogation of tolerogenic functions during an acute immunogenic maturation depended on an ablation of the tolerogenic conventional dendritic cell (cDC) population, resulting in a dynamic remodeling of the cDC functional landscape.

[Experimental & Molecular Medicine] Scientists suggested that inflammatory mediators in synovial fluid, including TNF-α, recruited sodium bicarbonate cotransporter n1 (NBCn1) to the plasma membrane of fibroblast-like synoviocytes to provide dynamic properties and that modulation of NBCn1 could be developed into a therapeutic strategy for rheumatoid arthritis.