SARS-CoV-2

[Science Signaling] The authors found that cell fusion caused by the SARS-CoV-2 spike protein induced a type I interferon response and that that cell fusion damaged nuclei and resulted in the formation of micronuclei that were sensed by the cytosolic DNA sensor cGAS and led to the activation of its downstream effector STING.

[Communications Biology] Researchers showed that the neutralizing activity of CV3-25 was maintained against the Alpha, Delta, Gamma and Omicron variants of concern as well as a SARS-CoV-like bat coronavirus with zoonotic potential by binding to a conserved linear peptide in the stem-helix region.

[Small] Scientists presented a systematic, comparative evaluation of various biologically derived nanoscale vesicles, which may be particularly well suited to sustained or repeated administration in the clinic due to low toxicity, and investigated their potential to inhibit multiple classes of model SARS-CoV-2 virions.

[Science Translational Medicine] The authors used a cell-free expression workflow to rapidly screen and optimize constructs containing multiple computationally designed miniprotein inhibitors of SARS-CoV-2.

[Cell Reports] Scientists reconstituted an in vitro pseudovirus-liposome fusion reaction and reported that SARS-CoV-2 wild-type spike was a dynamic Ca2+ sensor, and D614G mutation enhanced dynamic calcium sensitivity of spike protein for facilitating membrane fusion.

[Communications Biology] Researchers showed that the neutralizing activity of CV3-25 was maintained against the Alpha, Delta, Gamma and Omicron variants of concern as well as a SARS-CoV-like bat coronavirus with zoonotic potential by binding to a conserved linear peptide in the stem-helix region.