regulatory T cells

[Nature Communications] Researchers showed, using a genome-wide CRISPR knockout screen, that UBL3 was a necessary component of ubiquitination-mediated trafficking of major histocompatibility complex class II and CD86 in mice and in humans.

[Proceedings of the National Academy of Sciences of the United States of America] Using a range of mouse genetic models, researchers uncovered a critical tolerogenic axis between the autoimmune regulator, AIRE, and the immune checkpoint molecule, PD-1.

[Journal of Experimental Medicine] Using PDAC mouse models, scientists demonstrated that radiation therapy followed by anti-PD-1 antibody and prolonged treatment with CCR2/5i conferred better antitumor efficacy than other combination treatments tested.

[Nature Communications] Researchers showed, using a genome-wide CRISPR knockout screen, that UBL3 was a necessary component of ubiquitination-mediated trafficking of major histocompatibility complex class II and CD86 in mice and in humans.

[Proceedings of the National Academy of Sciences of the United States of America] Using a range of mouse genetic models, researchers uncovered a critical tolerogenic axis between the autoimmune regulator, AIRE, and the immune checkpoint molecule, PD-1.

[Journal of Experimental Medicine] Using PDAC mouse models, scientists demonstrated that radiation therapy followed by anti-PD-1 antibody and prolonged treatment with CCR2/5i conferred better antitumor efficacy than other combination treatments tested.