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Odoribacter splanchnicus-Derived Extracellular Vesicles Alleviate Inflammatory Bowel Disease by Modulating Gastrointestinal Inflammation and Intestinal Barrier Function via the NLRP3 Inflammasome Suppression

Researchers indicated that Odoribacter splanchnicus-extracellular vesicles (EVs) effectively ameliorated inflammatory bowel disease (IBD) through repressing NLRP3, strongly supporting the potential of probiotic-derived EVs for alleviating IBD. [Molecular Medicine] Full Article

A Single Cysteine Residue in Vimentin Regulates Long Non-Coding RNA XIST to Suppress Epithelial-Mesenchymal Transition and Stemness in Breast Cancer

Introduction of C328-VIM cells into nude mice promoted tumor growth by increasing cancer stemness in an oestrogen independent manner. [eLife] Full ArticlePress Release

Engineered Heart Muscle Allografts for Heart Repair in Primates and Humans

[Nature] Scientists investigated the hypothesis that epicardial engineered heart muscle allografts from iPSC-derived cardiomyocytes and stromal cells structurally and functionally remuscularized the chronically failing heart without limiting side effects in rhesus macaques.

MRPL24 Drives Breast Cancer Metastasis and Stemness by Targeting C-MYC, BRD4, and STAT3

Investigators explored the clinicopathological significance of MRPL24 in human cancers, with a particular focus on breast cancer. [3 Biotech] Abstract

LncRNA FGD5-AS1 Facilitates Hepatocellular Carcinoma Cell Stemness by Enhancing PKD1 mRNA Stability through Binding With MSI2

Both musashi 2 (MSI2) and protein kinase D1 (PKD1) ameliorated short hairpin-long noncoding RNA FGD5 antisense RNA 1's inhibition of hepatocellular carcinoma cell viability, proliferation, and stemness. [Molecular Carcinogenesis] Abstract

DNA Replication Stress Underpins the Vulnerability to Oxidative Phosphorylation Inhibition in Colorectal Cancer

Scientists showed that inhibiting oxidative phosphorylation similarly suppresses the proliferation and tumorigenicity of glycolytically competent colorectal cancer (CRC) cells in vitro and in patient-derived CRC xenografts. [Cell Death & Disease] Full Article

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