publication

Scientists isolated perineural invasion-associated cancer-associated fibroblasts (CAFs), which demonstrated a markedly enhanced capacity to promote neural invasion in pancreatic cancer compared to non-perineural invasion-associated CAFs [Cancer Research] Abstract

[Nature] Scientists examined immune diversity across tissues and identified a population of neutrophils in the skin that expressed a broad repertoire of proteins and enzymes needed to build the ECM.

[Advanced Science] To determine how Borrelia burgdorferi (Bb) extravasate from circulation and whether Bb can cross the blood–brain barrier, researchers imaged Bb-microvessel interactions in non-tissue-specific and brain-specific tissue-engineered microvessel models perfused with GFP-labeled Bb.

Researchers reported the design, synthesis, structure–activity relationship exploration and biological evaluation of a novel class of CRBN-recruiting cyclic GMP-AMP synthase (cGAS)-targeting PROTAC degraders. [Journal of Medicinal Chemistry] Abstract<a target='_blank' class='ga-link' href='Abstract' rel="noopener">Graphical Abstract

[Scientific Reports] Researchers examined the effect of the loss of Pol θ on expansion in fragile X-related disorder mouse ESCs, along with the effects of mutations in Rad52, Rad54l and Rad54b.

[Molecular Therapy - Nucleic Acids] Using CRISPR/Cas9 and transcription activator-like effector nucleases gene-editing tools, researchers corrected seven human iPSC cell lines derived from inherited retinal dystrophies patients carrying specific mutations.