pancreatic cancer cells

[Journal of Experimental & Clinical Cancer Research] Multiple bioinformatics analyses were used to evaluate zinc finger matrin-type 1 (ZMAT1) expression and potential role in PDAC.In vitro and in vivo studies were performed to assess the effects of ZMAT1 on PDAC cells growth.

[Frontiers in Oncology] Pancreatic cancer cells were used to verify the in vitro and in vivo effects of solasonine. Metabolomics were used to evaluate its underlying mechanisms. Solasonine promoted PANC-1 and CFPAC-1 cell apoptosis while inhibiting their proliferation, migration and invasion.

[Scientific Reports] Cell viability assay revealed that apiin, rhoifolin, and vitexin could inhibit proliferation of PANC-1 and ASPC-1, with rhoifolin showing the maximum inhibitory effect.

[Biochemical Society Transactions] Proteolytic shedding of multiple protein ectodomains by matrix metalloproteinase 7 (MMP-7) from pancreatic cancer cell surfaces influence apoptosis, proliferation, migration, and invasion.

[Immunologic Research] In this current study, the authors discovered that epidermal growth factor receptor affected major histocompatibility complex class I mRNA and protein expression by human pancreatic cancer cell lines.

[Cell Death & Disease] Investigators reported that USP49 stability was governed by F-box protein 45 (Fbxo45)-mediated ubiquitination and was enhanced by the absence of Fbxo45.