osteogenic differentiation

[Stem Cell Reviews and Reports] The authors summarize the types of MSCs that could be potentially applied in regenerative dentistry, the possible molecular cargos of MSC-extracellular vesicles (EVs), and the major effects of MSC-EVs on the therapeutic induction of osteogenic differentiation.

[Journal of Biomedical Materials Research Part B-Applied Biomaterials] A transwell migration assay was used to investigate recruitment of MDA-MB-231, MCF-7, and MDA-MB-453 breast cancer cells to the osseous polycaprolactone-nano-hydroxyapatite scaffolds.

[Small] Investigators developed a multifunctional nanocomposite bioink based on amine-functionalized copper-doped mesoporous bioactive glass nanoparticles and a hydrogel formulation that improved shape fidelity, and structural stability for extrusion-based bioprinting.

[Stem Cell Research & Therapy] The authors investigated the effect of hematopoietic cells on MSCs using various methods, including flow cytometry, adipogenic and osteogenic differentiation analysis, quantitative PCR, western bloting, and microCT analysis.

[Aging Cell] The authors screened the gene expression profiles of human bone marrow MSCs (BMSCs) from young and old donors and identified that elevation of the nucleosome assembly protein 1-like 2 (NAP1L2) expression was correlated with BMSC senescence and impaired osteogenesis.

[Cell Death Discovery] Scientists elucidated the role of miR-149 in osteogenic differentiation of MSCs and the underlying mechanism.