obesity

[Cell Death Discovery] Researchers suggested that fat mass and obesity-associated protein (FTO) suppressed prostate cancer proliferation and metastasis through reducing the degradation of CLIC4 mRNA in an m6A dependent manner.

[Epigenetics] Knockdown of fat mass and obesity-related protein (FTO) increased m6A methylation of TFPI-2 mRNA in pancreatic cancer (PC) cells, which increased mRNA stability via the m6A reader YTHDF1, resulting in up-regulation of TFPI-2 expression, and inhibited PC proliferation, colony formation, sphere formation, migration and invasion in vitro.

[Frontiers in Immunology] Scientists compared surface receptor expression and cytokine production between peripheral blood NK cells from 90 Type 2 diabetes mellitus patients and 62 age- and sex-matched healthy controls.

[Cell Death Discovery] IL-37 isoform D transgene amplified ST2+ immune cells, promoted M2 macrophage polarization and type 2 cytokine secretion in white adipose tissue that mediated beiging and inflammation resolution, thereby increasing energy expenditure, reducing obesity and insulin resistance in high-fat diet-fed mice.

[Trends in Endocrinology and Metabolism] The authors highlight the importance of studying pancreatic β-cell expansion and functional maturation signaling pathways and epigenetic programs to understand the causes of different forms of diabetes and to permit the design of novel therapeutic strategies.

[Nature Communications] Scientists reported that Sirt6, an anti-aging histone deacetylase, was critical in regulating myofiber configuration toward oxidative type and that Sirt6 activator could be an exercise mimetic.