neutrophils

[iScience] The authors hypothesized that viral mimic-priming improved mesnchymal stem cells' abilities to rebalance the dysregulated immune responses in COVID-19.

[Nature Reviews Clinical Oncology] Investigators review the phenotypic heterogeneity of intratumoral B cells and the importance of tertiary lymphoid structures (TLS) in their generation as well as the potential of B cells and TLS as prognostic and predictive biomarkers.

[Journal of Clinical Investigation] The authors observed increased plasma and platelet surface expressed high mobility group box 1 in stroke patients. Mechanistically, platelets were identified as the critical source for HMGB1 causing neutrophil extracellular trap in the acute phase of stroke.

[Science Translational Medicine] In human bronchial epithelial cells, phosphoinositide 3-kinase γ (PI3Kγ) mimetic peptide induced unexpected cyclic adenosine monophosphate and protein kinase A elevations restricted to the vicinity of the cystic fibrosis transmembrane conductance regulator (CFTR), the ion channel controlling mucus hydration that is mutated in CF.

[Nature Immunology] By tagging extracellular matrix around the mesothelium lining in mouse peritoneum, liver and cecum, scientists showed that preexisting matrix was transferred across organs into wounds in various injury models.

[Biochimica Et Biophysica Acta-Molecular Cell Research] Researchers investigated the effects of GRK2 inhibitors on neutrophil functions induced by GPR84 and FPR2 agonists. GRK2 was shown to be expressed in human neutrophils and analysis of subcellular fractions revealed a cytosolic localization.