neurons

[Scientific Reports] Human CB-MSCs were isolated and characterized using flow cytometry. Cell differentiation has been induced by combining retinoic acid and sonic hedgehog in a two-step protocol for 14 days.

[Frontiers in Molecular Neuroscience] Investigators tested the hypothesis that ZIKV-associated degeneration of neuronal processes was dependent on activation of Sterile alpha and armadillo motif-containing protein 1 (SARM1), an NADase that acted as a central executioner in a conserved axon degeneration pathway.

[Science Translational Medicine] Scientists reported that the orphan G protein–coupled receptor 177 (GPR177) in A-fiber neurons drove diabetic neuropathic pain via WNT5a-mediated activation of transient receptor potential vanilloid receptor-1 (TRPV1) ion channel.

[Molecular Neurodegeneration] Investigators performed a fluorescent cell sorting based genome-wide CRISPR-Cas9 screen in αS biosensors. αS and TDP-43 seeding activity under varied conditions was assessed using FRET/Flow biosensor cells or immunofluorescence for phosphorylated αS or TDP-43 in primary cultured neurons.

[Scientific Reports] Scientists explored miRNA profiles of CB-MSCs during differentiation into motor neuron-like cells.

[Cell Death & Disease] The authors showed that enterovirus 71 (EV71) engagement with intracellular receptor TLR9 elicited IL-12p40-iNOS signaling causing encephalitis in mice. They identified IL-12p40 to be the only prominent cytokine-induced at the early infection stage in the brainstem of mice subjected to a lethal dose of EV71.