neural stem cells

[Neoplasia] The authors demonstrated that induction of a CD24-positive population is one mechanism by which IDH-mutant tumors acquired stem-like properties.

[Neuro-Oncology] Scientists used single-cell RNA-sequencing to analyze new and recurrent glioblastoma, and the nearby subventricular zone. They found four glioblastoma neural lineages were present in new and recurrent glioblastoma with an enrichment of the cancer mesenchymal lineage, immune cells, and reactive astrocytes in early recurrences.

[Nature Neuroscience] Scientists found that a longer duration of epilepsy was associated with a sharp decline in neuronal production and persistent numbers in astrogenesis.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators showed that oleic acid was critical for neural stem cell survival and demonstrated that it binds to the nuclear receptor TLX to convert it from a transcriptional repressor to a transcriptional activator of cell-cycle and neurogenesis genes.

[Nature Biomedical Engineering] Researchers showed that patterned organoids and bioprinted tissues with controlled composition and organization could be generated by simultaneously co-differentiating hiPSCs into distinct cell types via the forced overexpression of transcription factors, independently of culture-media composition.

[Stem Cells] Scientists suggested that the asymmetric distribution of pericentrosomal CD133 endosomes induced the symmetry breaking of autophagic activity during cytokinesis in cooperation with nuclear β-catenin.