myeloid cells

[Immunology Letters] The authors summarize the current knowledge on the possible microglial states during development, homeostasis, and perturbation.

[Stem Cell Reviews and Reports] The authors focus on how to progress in vitro generation of platelets from stem cell, especially iPSCs, and describe some of the successful strategies that can be easily used in clinic.

[Nature Communications] Researchers showed, using a genome-wide CRISPR knockout screen, that UBL3 was a necessary component of ubiquitination-mediated trafficking of major histocompatibility complex class II and CD86 in mice and in humans.

[Circulation Research] Genetic deletion of pyruvate kinase muscle 2 (PKM2) in myeloid cells or limiting its nuclear translocation reduced atherosclerosis by suppressing inflammation and enhancing efferocytosis.

[Journal of Experimental Medicine] Using PDAC mouse models, scientists demonstrated that radiation therapy followed by anti-PD-1 antibody and prolonged treatment with CCR2/5i conferred better antitumor efficacy than other combination treatments tested.

[Nature Communications] Utilizing single-cell RNA and T cell receptor profiling, researchers showed that irrespective of STAT3 mutation status, T cell large granular lymphocytic leukemia clonotypes were more cytotoxic and exhausted than healthy reactive clonotypes.