melanoma

[Journal of Cellular and Molecular Medicine] Scientists found a novel chloroquine derivative, lj-2-66, that increased the level of reactive oxygen species (ROS) in melanoma cells and induced DNA damage, thus leading to G2/M arrest and apoptosis.

[Bioorganic Chemistry] Investigators evaluated the ability of pigment C-phycocyanin to bind to the main cellular targets related in the progression of melanoma through molecular docking, and the reflection of this bind in the biological effects in the B16F10 cell line through in vitro analysis.

[Oncogene] Scientists showed that a majority of human melanoma overexpressed discoidin domain receptor 2 after treatment.

[Naunyn-Schmiedebergs Archives of Pharmacology] Scientists discuss the advancement of PCSK9 research on its role and underlying mechanisms in tumor development and progression.

[Nature Communications] By investigating the resistance mechanisms, scientists found that MCL1 and JUNB modulated the mitochondrial apoptosis pathway. JUNB encoded a transcription factor that downregulates FasL and TRAIL receptors, upregulated the MCL1 relative BCL2A1, and activated the NF-κB pathway.

[Journal of Clinical Investigation] Scientists showed that human PD-1+Tim-3+ CD8+ tumor-infiltrating lymphocytes upregulated phosphatidylserine, a receptor for Tim-3, and acquire cell surface myeloid markers from antigen presenting cells through transfer of membrane fragments called trogocytosis.