melanocytes

[Photochemistry and Photobiology] Investigators examine DNA damage in melanoma cells (B16-F10) with different melanin contents, subjected to 1O2 generation and used the photosensitizer Rose Bengal acetate and irradiation with visible light.

[Scientific Reports] Researchers identified PPP6C, a serine/threonine phosphatase, as a key regulator of MITF in melanoma.

[Nature] Scientist sequenced the DNA of cutaneous and acral melanomas from a large cohort of human patients and found a specific enrichment for BRAF mutations in cutaneous melanoma and enrichment for CRKL amplifications in acral melanoma.

[Bioorganic Chemistry] Investigators evaluated the ability of pigment C-phycocyanin to bind to the main cellular targets related in the progression of melanoma through molecular docking, and the reflection of this bind in the biological effects in the B16F10 cell line through in vitro analysis.

[Pigment Cell & Melanoma Research] Researchers performed histology and immunohistochemistry analyses and demonstrated that a newly developed full-thickness 3D reconstructed human pigmented skin model and an epidermis-only model exhibit dispersed pigment throughout keratinocytes in the epidermis.

[Frontiers in Oncology] Investigators revealed that PLA2G6 was up-regulated in cutaneous malignant melanoma tissues compared to nevus tissues, as well as increased in vitro in SK-MEL-28 and M14 melanoma cell lines compared to human melanocytes.