megakaryocytes

[Stem Cell Reviews and Reports] The authors focus on how to progress in vitro generation of platelets from stem cell, especially iPSCs, and describe some of the successful strategies that can be easily used in clinic.

[Nature Communications] Researchers performed ischemia/reperfusion experiments in mice to assess the impact of genetic ACKR3 deficiency in platelets on tissue injury in ischemic myocardium and brain.

[Frontiers in Oncology] Investigators found that AML cells released a heterogeneous population of extracellular vesicles containing microRNAs involved in AML pathogenesis.

[Blood] Researchers found that Pf4-Grin1-/- mice had defects in megakaryopoiesis, thrombopoiesis and platelet function, which manifested as reduced platelet counts, lower rates of platelet production in the immune model of thrombocytopenia, and a prolonged tail bleeding time.

[Haematologica] Researchers used sera from 61 immune thrombocytopenia patients and assessed the capacity of antiplatelet antibodies to induce neuraminidase 1 surface expression, RCA-1 lectin binding and loss of mitochondrial inner membrane potential on donors’ platelets.

[Blood] Researchers found that megakaryocyte/platelet-specific lactate dehydrogenase A (LdhA)-knockout mice showed an increased number of platelets with remarkably accelerated megakaryocyte maturation and proplatelet formation.