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[Nature Communications] The authors combined genetic, epigenomic, and CRISPR activation approaches to screen for functional variants that regulated IRF8 expression and demonstrated that the locus containing rs2280381 was a cell-type-specific enhancer for IRF8 that spatially interacted with the IRF8 promoter.

[Experimental Dermatology] UVB-induced human endogenous retrovirus (HERV)-associated double-stranded RNA transcription and subsequent activation of the innate antiviral retinoic acid-inducible gene I(RIG-I)/MDA5/IRF7 pathway led to downstream transcription of interferon-stimulated genes, which promotes UVB-induced apoptosis and proliferation inhibition in keratinocytes

[Critical Journal of the American Society of Nephrology] Extracellular vesicles derived from reparative cells, such as mesenchymal stem cells, tubular epithelial progenitor cells, and human umbilical cord blood represent promising regenerative tools for treatment of kidney diseases.

[American Journal of Physiology-Renal Physiology] Scientists consider in-depth mechanisms of endothelial activation and the novel mechanism of endothelial antigen presentation.

[Allergology International] Few studies have examined in detail the relationship between drug eruptions, a major symptom of drug allergy, and systemic autoimmune diseases, and their actual status remains unclear.

[EMBO Journal] Scientists showed that the serine/threonine kinase AKT2 interacted with interferon regulatory factor 3 (IRF3) and phosphorylated it on Thr207, thereby attenuating IRF3 nuclear translocation in a 14-3-3ε-dependent manner and reducing induced type I interferon production.