kidney disease

[Clinical Science] The authors described a novel feedback loop composed of histone deacetylase 2 (HDAC2) and miR-205 that regulated ECM production in tubular epithelial cells in individuals with diabetic kidney disease.

[PLoS One] Through investigating chronic kidney disease-associated transcriptomics datasets, several proteases were highlighted including members of matrix metalloproteinases and serine proteases.

[Journal of the American Society of Nephrology] Scientists explore the mechanisms and detection of acute kidney injury in tissue culture, with an emphasis on bioengineered approaches such as human kidney organoid models.

[Environmental Toxicology] HK-2 cell viability and apoptosis were detected by Cell Counting Kit-8 assay and flow cytometry analysis, respectively. β-amyrin was found to ameliorate kidney injury in diabetic nephropathy mice and suppressed inflammatory response as well as apoptosis of HG-stimulated HK-2 cells.

[Journal of Tissue Engineering] Researchers investigated the therapeutic effects of exosomes secreted by melatonin-stimulated MSCs on the functional recovery of the kidney in a chronic kidney disease mouse model.

[Chinook Therapeutics, Inc.] Chinook Therapeutics, Inc. announced the formation of SanReno Therapeutics, a joint venture with an investor syndicate led by Frazier Healthcare Partners and Pivotal bioVenture Partners China, to develop, manufacture and commercialize kidney disease therapies in the People’s Republic of China, Hong Kong, Macau, Taiwan and Singapore.