kidney disease

[American Journal of Physiology-Renal Physiology] Scientists consider in-depth mechanisms of endothelial activation and the novel mechanism of endothelial antigen presentation.

[Science Translational Medicine] Single-nuclear RNA sequencing of kidney organoids after cisplatin exposure identified 159 differentially expressed genes and 29 signal pathways in tubular cells undergoing intrinsic repair.

[Frontiers in Immunology] The angiogenic potential of mesothelial cell-derived CXC chemokine ligand 1 (CXCL1) was assessed in vitro by measuring endothelial tube formation of human microvascular endothelial cells treated with conditioned medium from human peritoneal mesothelial cells stimulated to release CXCL1 by treatment with either recombinant IL-17 or peritoneal dialysis effluent.

[American Journal of Pathology] The authors discuss whether kidney organoids and tubuloids are suitable models for the study of complex human kidney disease and highlights their advantages and limitations compared with monolayer cell culture and animal models.

[Wyss Institute] A newly launched startup is building upon innovations developed over several years at the Wyss Institute, Harvard John A. Paulson School of Engineering & Applied Sciences, and Brigham and Women’s Hospital to engineer functional kidney tissue for renal repair and replacement therapy.

[Experimental Cell Research] Researchers established an in vitro VC model of vascular smooth muscle cells (VSMCs) and an adenine-induced CKD mouse model.