kidney cells

[Critical Journal of the American Society of Nephrology] Extracellular vesicles derived from reparative cells, such as mesenchymal stem cells, tubular epithelial progenitor cells, and human umbilical cord blood represent promising regenerative tools for treatment of kidney diseases.

[Journal of the American Society of Nephrology] Scientists used CRISPR-Cas9 gene editing of iPSCs to develop humanderived APOL1G0/G0 and APOL1G2/G2 kidney organoids on an isogenic background, and performed bulk RNA sequencing of organoids before and after treatment with IFN-γ.

[Molecular Medicine Reports] Chronic hypertension can lead to kidney damage, known as hypertensive nephropathy or hypertensive nephrosclerosis. The authors investigated the mechanisms by which endothelial progenitor cells repaired primary rat kidney cells.

[American Journal of Physiology-Lung Cellular and Molecular Physiology] A549 lung epithelial cells transfected with Klotho cDNA or vector were exposed to cigarette smoke; lactate dehydrogenase and double-strand DNA breaks were measured.

[Nature Communications] Researchers reported the generation of an expandable, 3D branching ureteric bud (UB) organoid culture model that could be derived from primary UB progenitors from mouse and human fetal kidneys, or generated de novo from human PSCs.

[Developmental Biology] The authors comprehensively assessed the vasculature in two distinct kidney organoid models as well as in explanted embryonic kidneys.