keratinocytes

[Pigment Cell & Melanoma Research] Researchers performed histology and immunohistochemistry analyses and demonstrated that a newly developed full-thickness 3D reconstructed human pigmented skin model and an epidermis-only model exhibit dispersed pigment throughout keratinocytes in the epidermis.

[Experimental Cell Research] Researchers studied the outcomes of olfactomedin 4 downregulation in human immortalized keratinocytes – the HaCaT cells.

[Experimental Dermatology] UVB-induced human endogenous retrovirus (HERV)-associated double-stranded RNA transcription and subsequent activation of the innate antiviral retinoic acid-inducible gene I(RIG-I)/MDA5/IRF7 pathway led to downstream transcription of interferon-stimulated genes, which promotes UVB-induced apoptosis and proliferation inhibition in keratinocytes

[JCI Insight] Investigators showed that matrix metalloproteinase 2, which degrades type IV collagen, was abundantly expressed in human skin, increased with age in sun-exposed skin, and correlated robustly with aryl hydrocarbon receptor (AhR), a transcription factor directly activated by UV-generated photometabolites.

[iScience] Scientists mapped the subcellular reorganization of the proteome of human keratinocytes in response to UVA light.

[iScience] The authors found that lysophosphatidic acid induced the differentiation of a previously unsuspected keratinocyte subpopulation expressing the extracellular matrix protein, thrombospondin-1 (THBS1).