interleukin-10

[Stem Cell Research & Therapy] Human umbilical cord-derived MSCs infusions improved systemic metabolic homeostasis and alleviated insulin resistance in epididymal adipose tissue but elicited no change in weight.

[Scientific Reports] Researchers examined whether haem oxygenase-1 (HO-1) could enhance the immunosuppressive effects of bone marrow MSCs (BMMSCs) on the rejection of transplanted liver allografts in rats.

[Nature Communications] Researchers showed that a subset of Interleukin-10-releasing HMOX1+ myeloid cells, spatially localizing to mesenchymal-like tumor regions, drove T cell exhaustion and thus contributed to the immunosuppressive tumor microenvironment.

[Biochemical Pharmacology] The authors explained the incidence of hand-foot skin reaction in patients treated with tyrosine kinase inhibitors by focusing on keratinocyte toxicity and inhibition of vascular endothelial growth factor receptor, which played an essential role in angiogenesis.

[Science Translational Medicine] Investigators evaluated the B cell subsets, Breg cell function, and the effect of B cell depletion therapy on these cells in patients with neuromyelitis optica spectrum disorder.

[Seminars in Immunology] Scientists summarize current insights into the mechanisms of macrophage-mediated host defense and repair during helminth infection and highlight recent progress on the immune regulatory crosstalk between macrophages and helminth parasites.