innate lymphoid cells

[Cell Reports] The authors demonstrate that innate lymphoid cells accumulated in the cerebral parenchyma, the choroid plexus, and the meninges in the onset of cerebral Toxoplasma gondii infection.

[Journal of Experimental Medicine] Genetic fate-mapping analysis revealed that liver Ly49E+ ILC1s with strong cytotoxicity originated from embryonic non–bone marrow hematopoietic progenitor cells, persisted locally during postnatal life, and mediated protective immunity against cytomegalovirus infection in newborn mice.

[Stem Cell Reviews and Reports] The authors describe the effects of various immune cells on intestinal stem cells (ISCs), as well as the mechanisms underlying these effects and also highlight the remarkable role of ISCs in intestinal pathogenesis.

[eLife] An observational study found that the abundance of innate lymphoid cells decreased more than 7-fold over the human lifespan - T cell subsets decreased less than two-fold - and is lower in males than in females.

[Science Translational Medicine] Reduced-intensity conditioning for HLA-haploidentical hematopoietic cell transplantation was augmented with same-donor memory-like natural killer (NK) cells on day +7 and 3 weeks of N-803 to treat patients with relapsed/refractory AML in a clinical trial.

[Science Immunology] Scientists used multiphoton intravital microscopy in mouse models of hepatitis B to study the intrahepatic behavior of group 1 innate lymphoid cells (ILCs) and their cross-talk with hepatitis B virus–specific CD8+ T cells.