induced pluripotent stem cells

[Kyodo News] A Japanese university research team has concluded that the world's first clinical trial, spanning over years, transplanting corneal tissues derived from induced pluripotent stem cells, or iPS cells, into four almost-blind patients was safe and effective.

[Stem Cells and Development] Researchers developed a pituitary-like organoid consisting only of gonadotrophs. Despite the lack of success in differentiating gonadotrophs, pituitary-like organoids were differentiated from human-induced pluripotent stem cells.

[Stem Cell Research] Human hiPSC clones NSi001-A, NSi001-B, and NSi001-C were generated from a female individual of Indian origin having Robertsonian translocation down syndrome by reprogramming peripheral blood mononuclear cells using integration-free Sendai viral vectors.

[Nature Neuroscience] Mutating endogenous FAN1 to a nuclease-inactive form in an induced pluripotent stem cell model of Huntington’s diseas led to rates of CAG expansion similar to those observed with complete FAN1 knockout.

[eLife] The authors used induced PSC technology to investigate whether murine mucosal-associated invariant T (MAIT) cells functioned as tumor-promoting or inhibitory cells. MAIT cells were reprogrammed into iPSCs and redifferentiated towards MAIT-like cells.

[Stem Cell Research] Scientists generated human induced pluripotent stem cells from fibroblasts of a 64-year-old male patient with a homozygous ILE368ASN mutation in PINK1, who experienced disease onset at 33 years.