induced pluripotent stem cells

[Science] The authors demonstrated the induction of functional primordial germ cell–like cells (PGCLCs) from rat PSCs. They showed that epiblast-like cells in floating aggregates formed rat PGCLCs.

[Nature Methods] Scientists overview the current effort to apply both human pluripotent stem cell-derived organoids and adult organoids to study SARS-CoV-2 tropism, host response and immune cell-mediated host damage, and perform drug discovery and vaccine development.

[Biosensors & Bioelectronics] Scientists reported Fourier light-field microscopy using a hybrid point-spread function for fast, volumetric, and high-resolution imaging of entire organoids.

[Open Biology] Investigators discuss the role of epigenetic and metabolic dysregulations and their cross-talk in tumorigenesis with a special focus on gliomagenesis.

[NPJ Regenerative Medicine] The embryonic development process and the pro-myogenic role of the muscle-resident cell populations in co-cultures are described, highlighting the possible clinical applications of induced pluripotent stem cells (iPSCs) in the skeletal muscle tissue engineering field.

[Cell Reports] The authors developed an efficient and scalable protocol to produce human pluripotent stem cell-derived liver sinusoidal endothelial cells progenitors characterized as venous endothelial cells from different mesoderm subpopulations.