in vivo

[Proceedings of the National Academy of Sciences of the United States of America] Researchers found that their engineered nanoparticles carrying a CpG DNA ligand of TLR9 could suppress tumor growth in several animal models of various cancers, resulting in an abscopal effect on distant tumors, and improving responsiveness to anti-CTLA4 treatment with combinatorial effects after intratumoral administration.

[Scientific Reports] Pregnant Balb/cByJ mice were intraperitoneally infected with 105 CFU of the 16 M reference strain, a 16 M mCherry mutant or a human isolate. Milk was collected over the course of lactation, and subjected to culture and immunofluorescence assays.

[Scientific Reports] Longitudinal echocardiography was used to assess whether NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ mice reconstituted with human hematopoietic stem cells and infected with HIV-1ADA could recapitulate the salient features of HIV-1 infection.

[Scientific Reports] Researchers evaluated the efficacy of the clade 2.3.2.1c and 2.3.4.4c H5Nx vaccines from the Korean avian influenza national antigen bank for emergency preparedness for their potency and protective efficacy against lethal homologous and heterologous viruses in layer and breeder chickens practically.

[Cell Reports] Leishmania-infected Tlr7−/− mice developed a chronic unhealing lesion, despite Th1 cell differentiation, and scientists showed that Tlr7−/− neutrophils alone mediated this effect. Conversely, topical treatment with a TLR7 agonist early in infection induced smaller lesion development than in untreated mice.

[Nature Communications] Researchers identified TBC1D15-mediated oncogenic mechanisms and tested the tumorigenic roles of TBC1D15 in vivo.