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in silico

Fast Growth Can Counteract Antibiotic Susceptibility in Shaping Microbial Community Resilience to Antibiotics

[Proceedings of the National Academy of Sciences of the United States of America] Researchers studied how bacterial growth dynamics could overcome differences in antibiotic susceptibility in determining community resilience: the recovery of the original community state following antibiotic exposure.

Fast Growth Can Counteract Antibiotic Susceptibility in Shaping Microbial Community Resilience to Antibiotics

[Proceedings of the National Academy of Sciences of the United States of America] Researchers studied how bacterial growth dynamics could overcome differences in antibiotic susceptibility in determining community resilience: the recovery of the original community state following antibiotic exposure.

Novel Integrated Workflow Allows Production and In-Depth Quality Assessment of Multifactorial Reprogrammed Skeletal Muscle Cells from Human Stem Cells

[Cellular and Molecular Life Sciences] Researchers developed a multifactor-based protocol that combined adenovector-mediated MYOD expression, small molecule inhibitor and growth factor treatment, and electrical pulse stimulation to efficiently reprogram different types of human-derived multipotent stem cells into physiologically functional skeletal muscle cells.

MicroRNA-22 Coordinates Vascular and Motor Neuronal Pathfinding via sema4 during Zebrafish Development

[Open Biology] Scientists showed that the deficiency of miRNA-22a, an endothelial-enriched miRNA, caused dramatic pathfinding defects both in intersegmental vessels and primary motor neurons in zebrafish embryos.

Mesenchymal Stem Cell-Derived Extracellular Vesicles in the Management of COVID19-Associated Lung Injury: A Review on Publications, Clinical Trials and Patent Landscape

[Journal of Tissue Engineering and Regenerative Medicine] The authors present the current landscape of the field and highlights some interesting findings on MSC-derived extracellular vesicles in the context of COVID-19, including in silico, in vitro, in vivo and case reports.

BCL6 and the Notch Pathway: A Signaling Axis Leading to a Novel Druggable Biotarget in Triple Negative Breast Cancer

[Cellular Oncology] Scientists investigated signaling cascades of B cell lymphoma 6 (BCL6) in the CSC compartment of triple negative breast cancers, and the mechanisms that govern its activity, mainly through Notch signaling.

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