histone acetylation

[Science Advances] Investigators reported that interleukin-4 –induced M0 → M2 macrophage polarization was accompanied by interchangeable glucose- or lactate-dependent tricarboxylic acid cycle metabolism that directly drove histone acetylation, M2 gene transcription, and functional immune suppression.

[Gene] Scientists investigated the effect of panobinostat, the broad-spectrum histone deacetylases inhibitor, on prostate cancer LNCaP and DU145 cell growth, and observed re-expression of hepatocyte cell adhesion molecule when treated with panobinostat.

[Cell Reports] Investigators showed that hypoxia-inducible factor 1α (HIF-1α) is required for NANOG-mediated breast CSC enrichment.

[Nature Aging] Researchers showed that aged mesenchymal stem cells exhibited reduced chromatin accessibility and lowered histone acetylation, particularly on promoters and enhancers of osteogenic genes.

[Pediatric Allergy and Immunology] Scientists aimed to investigate the role of MAPK signaling in childhood asthma and its environment-mediated protection, including a representative selection of 232 out of 1062 children from two cross-sectional cohorts and one birth cohort study.

[Cell Death & Disease] Integrated affinity purification combined with mass spectrometry and TCGA analysis identified a cell cycle-related E3 ubiquitin ligase, checkpoint with forkhead and ring finger domains (CHFR), as a key negative regulator of zinc finger E-box-binding homeobox 1 (ZEB1) in TNBC.