hepatocytes

[Scientific Reports] Scientists showed that the hepatic functions of hPSC-hepatocyte-like cells were facilitated by applying physiological liver temperatures during hepatic differentiation.

[Oncogene] The authors suggested that hepatocyte nuclear factor 4 alpha antisense RNA 1 (HNF4A-AS1)-encoded small 51-amino acid peptide promoted self-renewal and aggressive features of neuroblastoma stem cells by eEF1A1-repressed SMAD family member 4 (SMAD4) transactivation.

[iScience] Scientists demonstrated that syntaxin11 (STX11), a member of the SNARE family, generally expressed in immune cells, mediated lipid metabolism by binding to adipose-triglyceride-lipase (ATGL) and inhibiting lipid droplet degradation and lipid autophagy in hepatocytes.

[Journal of Cell Science] Cultured progenitor cells established from primary hepatocytes of Pkdcc knockout mice produced a secretome, which promoted their own proliferation in 3D spheroids and proliferation of cultured fibroblasts.

[Journal of Hepatology] Researchers investigated the role of X-box binding protein-1 (XBP1) in the progression of non-alcoholic steatohepatitis.

[Hepatology Communications] Researchers generated iPSC-derived hepatocytes and iPSC-derived cholangiocytes cells and characterized them based on hepatocyte-specific and cholangiocyte-specific markers.