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hepatic cells

HucMSC-Derived Exosomes Delivered BECN1 Induces Ferroptosis of Hepatic Stellate Cells via Regulating the xCT/GPX4 Axis

[Cell Death & Disease] Researchers studied the proferroptosis effect and mechanism of mesenchymal stem cell-ex in hepatic stellate cells.

Blocked Metabotropic Glutamate Receptor 5 Enhances Chemosensitivity in Hepatocellular Carcinoma and Attenuates Chemotoxicity in the Normal Liver by Regulating DNA Damage

[Cancer Gene Therapy] The authors investigated the differential regulatory effect of metabotropic glutamate receptor 5 on chemosensitivity in HCC and chemotoxicity to the normal liver.

Citrullination of Glucokinase Is Linked to Autoimmune Diabetes

[Nature Communications] Researchers showed the citrullination of pancreatic glucokinase as a result of inflammation, triggering autoimmunity and affecting glucokinase biological functions.

Disclosing the Antitumor Potential of the Marine Bromoditerpene Sphaerococcenol A on Distinct Cancer Cellular Models

[Biomedicine & Pharmacotherapy] Sphaerococcenol A capacity to impact colorectal-CSCs tumorspheres was evaluated by determining tumorspheres viability, number, and area, as well as the proteasome inhibitory activity.

GITR/GITRL Reverse Signaling Modulates the Proliferation of Hepatic Progenitor Cells by Recruiting ANXA2 to Phosphorylate ERK1/2 and Akt

[Cell Death & Disease] The authors identified reverse signaling between glucocorticoid-induced tumour necrosis factor receptor (GITR) and its ligand (GITRL) as a cross-interaction pathway between immune cells and hepatic stem/progenitor cells that restricted the expansion of hepatic stem/progenitor cells and reduced the possibility of carcinogenesis.

Specification of Fetal Liver Endothelial Progenitors to Functional Zonated Adult Sinusoids Requires C-maf Induction

[Cell Stem Cell] Scientists studied heterogeneity of hepatic vascular cells during mouse development through functional and single-cell RNA-sequencing.

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