epilepsy

[Nature Neuroscience] Scientists found that a longer duration of epilepsy was associated with a sharp decline in neuronal production and persistent numbers in astrogenesis.

[Biochemical and Biophysical Research Communications] Scientists investigated the molecular mechanism by which valproic acid inhibited rat vascular smooth muscle cell proliferation.

[Communications Biology] By promoting matrix-supported active cell reaggregation, the authors engineered multiregional cerebral tissues with intact 3D neuronal networks and functional interconnectivity characteristic of brain networks.

[Brain] To model human malformations of cortical development associated with nitrogen permease regulator-like 3 (NPRL3) variants, researchers created a focal Nprl3 KO in fetal mouse cortex by in utero electroporation and found altered cortical lamination and white matter heterotopic neurons

[Science] Investigators generated a human model for tuberous sclerosis complex (TSC) by growing cerebral organoids from patients who carried mutations in TSC2.

[Frontiers in Molecular Neuroscience] Brain organoids capture the developmental progression of the human brain and contain human-enriched progenitor cell types.