endothelial cells

[Current Topics in Developmental Biology] Scientists review what's been learned from embryonic blood vessels and how this knowledge instructs our approaches to vascularize laboratory generated tissues, such as organoids.

[Nature] Scientists created a single-cell transcriptome map of human hematopoietic tissues from the first trimester to birth and found that the hematopoietic stem cell (HSC) signature RUNX1+HOXA9+MLLT3+MECOM+HLF+SPINK2+ distinguished HSCs from progenitors throughout gestation.

[Cell Death & Disease] Scientists evaluated the anti-inflammatory effects and potential mechanisms of action of 3TC in vitro in retinal microvascular endothelial cells treated with high-glucose and lipopolysaccharide.

[Nature Cardiovascular Research] Investigators characterized vascular aberrancies induced by myocardial infarction (MI) and proposed to target acquired endothelial cell changes to normalize vessels and promote cardiac repair after MI.

[Nature Cardiovascular Research] The authors described AAV-BI30, a capsid that specifically and efficiently transduces endothelial cells throughout the central nervous system.

[BMC Pulmonary Medicine] In vitro, Jagged1 was found to be activated by Notch1 in MSCs, resulting in the RBP-Jκ-dependent expression of Jagged1 mRNA, a response that was blocked by Notch1 inhibition.