embryonic stem cells

[Oncology Reports] Investigators aimed to examine the stemness‑inhibitory effects of dinaciclib in MCF‑7 and HCC‑1806 breast cancer cells.

[STAR Protocols] This protocol describes how to generate lung organoids from human embryonic stem cells. Lung organoids form by self-assembly in Matrigel and contain lung epithelial cell types.

[Nature Cell Biology] Investigators observed that initiation of differentiation in iPSCs and ESCs triggered widespread apoptosis, followed by a synchronous epithelial–mesenchymal transition.

[Nature] The authors demonstrated, by creating an intermediate plastic state, the chemical reprogramming of human somatic cells to human chemically iPSCs that exhibited key features of ESCs.

[Stem Cell Reviews and Reports] The authors focus on how to progress in vitro generation of platelets from stem cell, especially iPSCs, and describe some of the successful strategies that can be easily used in clinic.

[Genome Research] Investigators used a mESC model to describe in detail the relationships within the H3K27-H3K36-DNA methylation subnetwork, with a focus on the major epigenetic reorganization caused by deletion of the histone 3 lysine 36 methyltransferase NSD1, which in mESCs deposits nearly all of the intergenic H3K36me2.