dermal cells

[Journal of Investigative Dermatology] Investigators confirmed that the rosacea-like skin inflammation induced by Cathelicidin LL37 was alleviated in aged mice and mice with progeria.

[Photochemistry and Photobiology] Investigators examine DNA damage in melanoma cells (B16-F10) with different melanin contents, subjected to 1O2 generation and used the photosensitizer Rose Bengal acetate and irradiation with visible light.

[Microscopy Research and Technique] Investigators used an organotypic model of wound healing and we seeded keratinocytes on a adipose-derived MSC-induced dermal matrix. Conventional hematoxylin–eosin stain and immunohistochemistry staining for Ki67, p63 and pan-keratins were performed at different timepoints.

[Scientific Reports] Researchers identified PPP6C, a serine/threonine phosphatase, as a key regulator of MITF in melanoma.

[Molecular and Cellular Biochemistry] The authors focuse on a deeper understanding of the possible role of proliferator-activated receptor γ (PPARγ) in the pathogenesis of psoriasis and the potential of PPARγ agonist to improve the treatment of psoriasis.

[Photochemistry and Photobiology] Though nobiletin limited UVB-irradiated human keratinocytes from undergoing cell death, researchers found that this enhanced survival was not associated with increased nucleotide excision repair or XPA expression. Instead, nobiletin reduced initial UV photoproduct formation and promoted a G1 cell cycle arrest.