dendritic cells

[Cell Reports] Scientists revealed that the abrogation of tolerogenic functions during an acute immunogenic maturation depended on an ablation of the tolerogenic conventional dendritic cell (cDC) population, resulting in a dynamic remodeling of the cDC functional landscape.

[Nature Nanotechnology] Researchers described a genetically engineered cell membrane nanovesicle that integrated antigen self-presentation and immunosuppression reversal for cancer immunotherapy.

[Cancer Cell International] The authors indicated a relationship between synaptosome associated protein 25 (SNAP25) expression and prostate cancer, demonstrating that SNAP25 was a potential prognostic biomarker due to its vital role in immune infiltration.

[Science Immunology] The authors review both antitumor and tolerogenic dendritic cell (DC) responses in cancer and discuss lineage-specific contributions by their functionally specialized subsets, including the conventional DC (cDC) subsets cDC1 and cDC2, the newly described DC3, and the plasmacytoid DCs (pDCs), focusing on the human setting.

[Immunity] Scientists identified transcriptionally distinct exhausted T cell subpopulations, mapped their differentiation trajectories via transitory cellular states toward exhausted CD8+ T cells, and localized these cell states to specific splenic niches.

[Cell Death Discovery] Scientists found that specific deletion of Cbl-b and c-Cbl in CD11c+ cells, predominantly in dendritic cells (DCs), led to liver fibrosis, cirrhosis, and accumulation of systemic conventional Type I DCs due to enhanced cell proliferation and decreased cell apoptosis.